Immunological Tolerance
John Wiley & Sons Ltd (Verlag)
978-0-471-97843-5 (ISBN)
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This text brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T-cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T-cell activation, and the role of apoptosis in tolerance. Consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T-cell activation during tumour therapy, anti-antigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy, and tolerance during various autoimmune diseases.
Mechanisms of peripheral T-cell tolerance; molecular and genetic mechanisms for maintaining self-tolerance in B-cells; mechanisms and consequences of partial T-cell activation; tolerance and determinant hierarchy; molecular recognition of the T-lymphocyte responses in the healthy and diseased immune system; co-stimulatory and inhibitory aspects of T-cell activation; antigen-specific CD4+ T-cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect; antigen-specific immune suppression - tolerance or what?; tolerance induction to transplanted tissues using monoclonal antibodies (What are the mechanisms?); two-step induction of autoimmunity involving reversal of tolerance and conditioning of the target organ; cross-presentation of self antigen to CD8+ T-cells - the balance between tolerance and autoimmunity; tolerance induction in mature T-lymphocytes; T-lymphocyte mediated control of autoimmunity.
| Erscheint lt. Verlag | 23.7.1998 |
|---|---|
| Reihe/Serie | Novartis Foundation Symposia ; 215 |
| Zusatzinfo | indexes, references |
| Verlagsort | Chichester |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 530 g |
| Themenwelt | Studium ► Querschnittsbereiche ► Infektiologie / Immunologie |
| Naturwissenschaften ► Biologie ► Biochemie | |
| ISBN-10 | 0-471-97843-4 / 0471978434 |
| ISBN-13 | 978-0-471-97843-5 / 9780471978435 |
| Zustand | Neuware |
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