Pharmacogenomics in Drug Discovery and Development

Qing Yan (Herausgeber)

Buch | Hardcover

616 Seiten

2022 | 3rd ed. 2022
Springer-Verlag New York Inc.
978-1-0716-2572-9 (ISBN)

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This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care.
Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Target Discovery for Drug Development Using Mendelian Randomization.- Human Leukocyte Antigen (HLA) Testing in Pharmacogenomics.- Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer.- Pharmacogenomics in Cytotoxic Chemotherapy of Cancer.- Management of Side Effects in the Personalized Medicine Era: Chemotherapy-Induced Peripheral Neuropathy.- The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine.- Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next Generation Sequencing Data.- COVID-19 Pharmacotherapy: Drug Development, Repurposing of Drugs, and the Role of Pharmacogenomics.- Pharmacogenomics Informs Cardiovascular Pharmacotherapy.- Pharmacogenomic Screening of Patient-Specific hiPSC-Derived Cardiomyocyte Drug Candidates Using High-Throughput Calcium Imaging.- The Yin-Yang Dynamics in Cardiovascular Pharmacogenomics and Personalized Medicine.- GTPgS Assay for Measuring Agonist-Induced Desensitization of Two Human Polymorphic Alpha2B-Adrenoceptor Variants.- Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development.- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.- The Pharmacogenetic Impact on the Pharmacokinetics of ADHD Medications.- Pharmacogenetics of Addiction Therapy.- Pharmacogenomics of Opioid Treatment for Pain Management.- The Role of Pharmacogenomics in Postoperative Pain Management.- Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis.- Pharmacogenomics in Children.- Genetic Ancestry Inference for Pharmacogenomics.

Erscheinungsdatum	09.09.2022
Reihe/Serie	Methods in Molecular Biology ; 2547
Zusatzinfo	47 Illustrations, color; 7 Illustrations, black and white; XIV, 616 p. 54 illus., 47 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Human-drug-environment interactions • Individualized health care • Personalized medicine • Preventative medicine • systems biology • Therapeutic design
ISBN-10	1-0716-2572-1 / 1071625721
ISBN-13	978-1-0716-2572-9 / 9781071625729
Zustand	Neuware