Protein-protein Complexes: Analysis, Modeling And Drug Design (eBook)

Zacharias Martin Zacharias (Herausgeber)

eBook Download: PDF

2010
400 Seiten
World Scientific Publishing Company (Verlag)
978-1-908978-54-7 (ISBN)

Infos

Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

Produkt-Details

• Erscheint lt. Verlag: 4.5.2010
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• ISBN-10: 1-908978-54-6 / 1908978546
• ISBN-13: 978-1-908978-54-7 / 9781908978547