Science of Synthesis: Click Chemistry
Click chemistry is a discipline that has grown rapidly since the introduction of this term by Barry Sharpless and Huisgen approximately two decades ago. Initially, click reactions mostly involved copper-catalyzed azide-alkyne cycloadditions and their applications to connect molecules, but gradually new types of click reactions were developed which also allowed a much wider range of applications throughout the chemical, biological, and materials sciences. This volume provides an overview of the most widely used click reactions and their scope and limitations. Written by pioneers and leaders in the field and including representative applications and experimental procedures. Newcomers to the field are enabled to instantly apply these reactions in synthesis.
lt;p>1 Introduction
2 Copper-Catalyzed Azide Alkyne Cycloaddition (CuAAC)
3 Ruthenium-Catalyzed Azide Alkyne Cycloaddition (RuAAC)
4 Metal-Free Click Reactions between 1,3-Dipoles and Alkynes/Alkenes
5 Sulfur Fluoride Exchange (SuFEx)
6 Thiol-Based Click Reactions
7 Tetrazine-Based Cycloadditions in Click Chemistry
8 Sydnone-Based Cycloadditions in Click Chemistry
| Erscheinungsdatum | 16.11.2021 |
|---|---|
| Reihe/Serie | Science of Synthesis |
| Verlagsort | Stuttgart |
| Sprache | englisch |
| Maße | 170 x 255 mm |
| Gewicht | 1532 g |
| Themenwelt | Naturwissenschaften ► Chemie ► Organische Chemie |
| Schlagworte | 1,3-dipolar cycloadditions • bio-orthogonal chemistry • carbohydrate conjugation • copper-catalyzed azide-alkyne cycloaddition (CuAAC) • drug discovery • Protein conjugation • strain-promoted azide-alkyne cycloaddition (SPAAC) • sulfur-fluoride exchange (SuFEx) • Tetrazines |
| ISBN-10 | 3-13-243556-2 / 3132435562 |
| ISBN-13 | 978-3-13-243556-8 / 9783132435568 |
| Zustand | Neuware |
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