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Drug Discovery and Development, Third Edition -

Drug Discovery and Development, Third Edition

Buch | Softcover
696 Seiten
2021 | 3rd edition
CRC Press (Verlag)
978-1-032-08424-4 (ISBN)
CHF 79,95 inkl. MwSt
The third edition of The Process of New Drug Discovery and Development presents a practical methodology and up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace.
Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.

Features:










Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries







Case study detailing the discovery of the anti-cancer drug, lorlatinib







Venture capitalist commentary on trends and best practices in drug discovery and development







Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding







Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research



Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

James J. O'Donnell, James T. O'Donnell

Acknowledgments

Introduction to the First Edition (1992)

Introduction to the Second Edition (2006)

Editors

Contributors



Chapter 1: Introduction to Drug Discovery and Development

James J. O’Donnell III, John C. Somberg, and James T. O’Donnell



SECTION I Overview

Chapter 2: Current Opinions on the Trajectory of the Pharmaceutical Development

John C. Somberg



Chapter 3: Innovation in Drug Development: Perspectives of a Venture Capitalist

Krishna Yeshwant



SECTION II Drug Discovery

Chapter 4: High-Throughput Screening

Olivia Perez, J. Pena, Virneliz Fernandez-Vega, Louis Scampavia, and Timothy Spicer



Chapter 5: DNA-Encoded Compound Libraries: An Emerging Paradigm in Drug Hit Discovery

Raphael M. Franzini



Chapter 6: Bio-Targeted Nanomaterials for Theranostic Applications

Sabyasachi Maiti and Kalyan Kumar Sen



Chapter 7: The Development of Adoptive T-Cell Immunotherapies for Cancer: Challenges and Prospects

David J. Dow, Steven J. Howe, Mala K. Talekar, and Laura A. Johnson



Chapter 8: CRISPR in Drug Discovery

Chih-Shia Lee and Ji Luo



Chapter 9: Probiotics in the World: “Bugs-as-Drugs”

Thomas Kuntz, Madeline Kim, Elle Simone Hill, Mariana C. Salas Garcia, and Jack A. Gilbert



Chapter 10: Discovery and Early Development of the Next-Generation ALK Inhibitor, Lorlatinib (18): Agent for Non·Small-Cell Lung Cancer

Paul F. Richardson



SECTION III Drug Development

Chapter 11: Integrated Drug Product Development: From Lead Candidate Selection to Life-Cycle Management

Madhu Pudipeddi, Abu T.M. Serajuddin, Ankita V. Shah, and Daniel Mufson



Chapter 12: New Trends in Pharmacological and Pharmaceutical Profiling

Lyn Rosenbrier Ribeiro, Duncan Armstrong, Thierry Jean, and Jean-Pierre Valentin



Chapter 13: Pharmacokinetics·Pharmacodynamics in New Drug Development

Sarfaraz K. Niazi



Chapter 14: The Evolving Role of the Caco-2 Cell Model to Estimate Intestinal Absorption Potential and Elucidate Transport Mechanisms

Jibin Li and Ismael J. Hidalgo



Chapter 15: Preclinical Toxicology

Damani Parran



Chapter 16: Safety Pharmacology: Past, Present, and Future

Jean-Pierre Valentin, Annie Delaunois, Marie-Luce Rosseels, Vitalina Gryshkova, and Tim G. Hammond



Chapter 17: Ethical Concerns in Clinical Research

Jonathan C. Young and Lori Nesbitt



Chapter 18: Clinical Trials Methodology

John Somberg



Chapter 19: The Academic Research Enterprise

Crista Brawley, Mary Jane Welch, Jeff Oswald, Erin Kampschmidt, Jennifer Garcia, Allecia Harley, Shrijay Vijayan, John McClatchy, Stephanie Guzik, and Stephanie Tedford



Chapter 20: Clinical Testing Challenges in HIV/AIDS Research

Vincent Idemyor



Chapter 21: The Evolving Role of the Pharmacist in Clinical, Academic, and Industry Sectors

Gourang Patel and Stephanie Tedford



Chapter 22: Intellectual Property in the Drug Discovery Process

Martha M. Rumore and William Schmidt



Chapter 23: Drug Repurposing: Academic Clinician Research Endeavors

Kathleen Heneghan and Stephanie E. Tedford



SECTION IV Regulations

Chapter 24: The Role of the Regulatory Affairs Professional in Guiding New Drug Research, Development, and Approval

S. Albert Edwards



Chapter 25: Orphan Drug Development and Regulations

A.M. Lynch



Chapter 26: Development of Drug Products for Older Adults: Challenges, Solutions, and Regulatory Considerations

S.W. Johnny Lau, Darrell R. Abernethy, and Chandrahas Sahajwalla



Chapter 27: Clinical Pharmacology and Regulatory Concerns for Developing Drug Products for Pediatric Patients

Janelle M. Burnham and Gilbert J. Burckart



Chapter 28: Pharmacy Compounding Regulations

Loyd V. Allen, Jr. and Willis C. Triplett



Index

Erscheinungsdatum
Zusatzinfo 21 Illustrations, color; 77 Illustrations, black and white
Verlagsort London
Sprache englisch
Maße 178 x 254 mm
Gewicht 1283 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Naturwissenschaften Biologie
Technik
ISBN-10 1-032-08424-3 / 1032084243
ISBN-13 978-1-032-08424-4 / 9781032084244
Zustand Neuware
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