Comprehensive Glycoscience

Media-Kombination

2964 Seiten

2021 | 2nd edition
Elsevier Science Publishing Co Inc
978-0-12-819475-1 (ISBN)

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Comprehensive Glycoscience, Second Edition, Five Volume Set assembles the top minds in this area who provide an update on the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections.

Dr. Barchi received his Ph.D. in Synthetic/Marine Natural Products Chemistry from the University of Hawaii and was a postdoctoral fellow at Duke University. He then joined the National Cancer Institute as a staff fellow in the Laboratory of Medicinal Chemistry in1988 where he rose to his current position of Senior Scientist/Principal Investigator and NMR Facility Head at the newly formed Chemical Biology Laboratory. His main research interests are in synthetic medicinal chemistry as it relates to carbohydrate-based drug design, the development of novel sugar-conjugated nanoparticles and the high-resolution structural analysis of sugars, glycopeptides and small molecule drug candidates by NMR spectroscopy. Dr Barchi’s career at the NCI has spanned a wide breadth of drug discovery efforts, including the synthesis of PKC and reverse transcriptase inhibitors, the development of glycopeptide antigens as vaccine candidates against HIV and cancer, as well as the discovery of several glycopeptide-analogues of Antiproliferative Factor (APF), a negative growth factor isolated from patients with interstitial cystitis. Current focus in the lab is the discovery of novel nanoplatforms for the delivery and therapeutic applications of immunogenic glycopeptides, the search for selective antitumor agents based on APF and the conformational analysis of these synthetic analogues by NMR spectroscopy to guide further discovery efforts. He is on the editorial board of Current Cancer Drug Targets (Bentham Science Publishers) and Carbohydrate Research (Elsevier) and was a guest editor for Current Topics in Medicinal Chemistry (Bentham Science Publishers), on The Art of Drug Design and Discovery. He has an h-index of 35.

1. Introduction to Glycoscience, Glycan Structure and Function Joseph J. Barchi, Jr., Center for Cancer Research, Frederick, MD, USA 2. Analysis and Preparation of Glycans Dr Sébastien Vidal, French National Centre for Scientific Research (CNRS), France 3. Cellular Glycobiology and Interactions of Glycans Professor Spencer Williams University of Melbourne, Australia 4. Glycan Materials, Arrays and Nanotechnology Professor Ravin Narain, University of Alberta, Canada 5. Glycans in Development, Health and Disease Professor Naoyuki Taniguchi, Osaka International Cancer Institute, Japan

Erscheint lt. Verlag	29.6.2021
Mitarbeit	Chef-Herausgeber: Joseph J Barchi Jr
Sprache	englisch
Maße	216 x 276 mm
Gewicht	5000 g
Themenwelt	Naturwissenschaften ► Chemie ► Analytische Chemie
ISBN-10	0-12-819475-8 / 0128194758
ISBN-13	978-0-12-819475-1 / 9780128194751
Zustand	Neuware