Hematologic Malignancies

Case Studies in Cytogenetic and Molecular Genetics

Manorama Bhargava (Autor)

Buch | Hardcover

246 Seiten

2021 | 1st ed. 2021
Springer Verlag, Singapore
978-981-334-798-4 (ISBN)

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This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.

Dr. Bhargava has served as a Professor and Head, Department of Hematology at the prestigious All India Institute of Medical Sciences until September 2001, Sir Ganga Ram Hospital till 2016 and as Senior Advisor and Head Hematopathology at Medanta, The Medicity until May 2020. Dr. Bhargava is a pioneer in Hematology in India and is widely recognised for her contributions to Hematology both nationally and internationally. In a career spanning almost 50 years, she advocated and brought awareness for hematology as a discipline separate from Internal Medicine and Pathology where it constituted a minor part. Recipient of prestigious fellowships such as Alexander Von Humboldt, Fogarty and INSA fellowships. She has been principal investigator on several research grants, notably Indo-US, Indo-French, Indo–German and Indo-Japan grants and has published more than 300 articles in national and international journals. In recognition of her contributions to Hematology, she was awarded the Dr. B.C. Roy National Award and the highest award of Indian Council of Medical Research, the Basanti Devi Amirchand prize. An acclaimed teacher, she established the first ever superspecialty degrees of DM in clinical Hematology and DM in Hematapathology in the year 2000 at the All India Institute of Medical Sciences and the Diplomate National Board in Hematology in 2008.

Techniques in Cytogenetics.- Techniques in Molecular Haematology.- Part: I - Case Studies in Myeloid Malignancies.- Acute Myeloid Leukemia.- Myelodysplastic Syndrome.- Myelodysplastic Syndromes - Myeloproliferative Neoplasms.- Myeloproliferative Neoplasms.- Chronic Myeloid Leukemia.- Next Generation Sequencing for Diagnostics of Myeloid Malignancies for Routine Clinical Use: Pitfalls and Advantages.- Part: II - Case Studies in Lymphoid Malignancies.- Acute Lymphoblastic Leukemia.- Chronic Lymphocytic Leukemia and Non Hodgkin’s Lymphoma.- Part: III - Case Studies in Multiple Myeloma.- Multiple Myeloma.

Erscheinungsdatum	24.02.2021
Zusatzinfo	114 Illustrations, color; 118 Illustrations, black and white; XXVI, 246 p. 232 illus., 114 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Hämatologie
	Medizinische Fachgebiete ► Innere Medizin ► Hepatologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► 2. Studienabschnitt (Klinik) ► Pathologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	AML, ALL, CML, MDS, MM • Case studies in Cytogenetics • Case studies in Hematology • Case studies in molecular hematology • cytogenetics • Molecular hematology
ISBN-10	981-334-798-8 / 9813347988
ISBN-13	978-981-334-798-4 / 9789813347984
Zustand	Neuware