Advances in Chemical Proteomics

Buch | Softcover

268 Seiten

2021
Elsevier Science Publishing Co Inc (Verlag)
978-0-12-821433-6 (ISBN)

Artikel merken

Advances in Chemical Proteomics provides essential concepts and recent applications on probes, tool compounds and concepts for chemical proteomics and then moves on to applications, including solid-phase reagents, fragment screening, designer compounds and protein lipidation. As the second volume in the Developments in Organic Chemistry series, each chapter is written by experts in the field. Users will find this to be a valuable reference for organic chemists and chemical biologists who are interested in developing tool compounds and reagents to measure and interrogate proteome, develop drug leads, and measure off-target effects and drug toxicity.

Analytical chemists who are interested in better understanding organic chemistry behind commonly used reagents for quantitative proteomics and tools compounds in the emerging field of chemical proteomics will also benefit from this comprehensive resource on the topics presented.

Xudong Yao obtained his B.S. in synthetic polymer materials in July 1984 and M.S. in polymer chemistry in July 1987, both from Nanjing University in China. After working with the Department of Fiber Materials at China Textile University (now Donghua University) in Shanghai, he moved to the University of Maryland Baltimore County in the United States for doctoral studies in mechanistic enzymology with Prof. Ralph M. Pollack from August 1995 to October 1999. He then waded into the beginning streams of proteomics and did postdoctoral research in mass spectrometry and proteomics with Prof. Catherine Fenselau in the Department of Chemistry and Biochemistry at the University of Maryland until March 2002. During that time, he co-invented a highly cited quantitative proteomics technology of enzymatic 18O-labeling. Recruited by GeneProt, he flew to Geneva to join an ahead-of-its-time venture on proteomics industrialization. In October 2002, he joined Millennium Pharmaceuticals in Boston, continuing his industrial exploration in the uncharted land of Antibody-drug conjugates using mass spectrometry. He resumed his academic pursuit in August 2004, joining the Department of Chemistry at the University of Connecticut where he currently is an associate professor. His research activities are centered on the development and application of novel mass spectrometry and omics technologies.

1. Tool compounds for mass spectrometry-based chemical proteomics 2. Principles of proteomic reactions of covalent inhibitors 3. Reporter tags and chemistry for probe-reacted proteins 4. Chemical derivatization of peptides for quantitative proteomics 5. Database-searching strategies for probe-reacted proteins in a proteome 6. Solid-phase reagents for discovering inhibitors of kinases 7. Fragment screening for discovering covalent probes 8. Designer compounds for locational proteomics 9. Chemical proteomics for exploring protein lipidation Targeting Author: Edward Tate 10. Synthetic evolution of indocyanine green with the 2-nitroimidazole warhead for imaging of hypoxic tumor

Erscheinungsdatum	28.10.2021
Reihe/Serie	Developments in Organic Chemistry
Sprache	englisch
Maße	152 x 229 mm
Gewicht	410 g
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	0-12-821433-3 / 0128214333
ISBN-13	978-0-12-821433-6 / 9780128214336
Zustand	Neuware