Immunology and Evolution of Infectious Disease (eBook)

Steven A. Frank (Autor)

eBook Download: PDF

2020
360 Seiten
Princeton University Press (Verlag)
978-0-691-22016-1 (ISBN)

Infos

From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine.The author uses an evolutionary perspective to meld the terms and findings of molecular biology, immunology, pathogen biology, and population dynamics. This multidisciplinary approach offers newcomers a readable introduction while giving specialists an invaluable guide to allied subjects. Every aspect of the immune response is presented in the functional context of parasite recognition and defense--an emphasis that gives structure to a tremendous amount of data and brings into sharp focus the great complexity of immunology. The problems that end each chapter set the challenge for future research, and the text includes extensive discussion of HIV, influenza, foot-and-mouth disease, and many other pathogens.This is the only book that treats in an integrated way all factors affecting variation in infectious disease. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For molecular biologists, immunologists, and evolutionary biologists, this book provides new insight into infectious agents, immunity, and the evolution of infectious disease.

Produkt-Details

• Erscheint lt. Verlag: 6.10.2020
• Zusatzinfo: 40 line illus.
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Schlagworte: adaptive immune system • Affinity maturation • Allele • Amino acid • Amino Acid Substitution • antibodies • Antibody • antibody binding • Antigen • Antigenicity • Antigenic site • Antigenic variation • archival library of variants • assay • Bacteria • B Cell • Biology • Borrelia hermsii • CCR5 • CD4 • CD8 • cell division • cell type • chromosome • Circumsporozoite protein • Cross-reactivity • Cytokine • cytopathic versus noncytopathic • Cytotoxic T cell • Dengue virus • Disease • Dosage • Enzyme • Epitope • Epstein-Barr virus • equilibrium affinity • Escherichia coli • Evolution • evolutionary dynamics • experimental evolution • fimbriae • Gene • gene expression • Generative Mechanisms • genetic variability • genetic variation • Genotype • geographic scale • germline • helper T cells • Hemagglutinin • Hemagglutinin (influenza) • heparan sulfate (HS) • Hepatitis B Virus • Host (biology) • Human T-lymphotropic virus 1 • IgG • immune regulation • Immunity (medical) • immunodominance • Immunogenicity • Immunoglobulin G • Immunoglobulin M • Infection • Influenza • influenza A virus • Influenza A virus subtype H1N1 • inoculation • in vitro • In vivo • Ligand (biochemistry) • Linkage Disequilibrium • Listeria monocytogenes • macrophage • Malaria • measles • MHC class I • MHC class II • MHC polymorphism • mixotope • Molecule • monoclonal antibody • murine leukemia virus • Mutagenesis • Mutation • mutation rate • National Science Foundation • Neisseria gonorrhoeae • Neurospora crassa • Nucleic acid sequence • Nucleotide • organism • original antigenic sin • Parasitemia • parasitism • pathogen • Peptide • persistent infection • Phenotype • Phylogenetics • Plasmodium • Plasmodium Falciparum • Point mutation • population dynamics • Population Size • Protein • Reassortment • Receptor (biochemistry) • red blood cell • RNA virus • rotavirus • Salmonella enterica • Serial passage • Serotype • somatic hypermutation • Stimulation • Symptom • T Cell • T cell receptor • T Helper Cell • Tissue tropism • Trypanosoma brucei • Virus • West Nile virus • white blood cell • Yellow Fever Virus
• ISBN-10: 0-691-22016-6 / 0691220166
• ISBN-13: 978-0-691-22016-1 / 9780691220161