Biological Reaction Engineering

Dynamic Modelling Fundamentals with Simulation Examples

Irving J. Dunn, Elmar Heinzle, John Ingham, Jiri E. Prenosil (Autoren)

Buch | Hardcover

XVI, 508 Seiten

2003 | 2., vollst. überarb. u. erw. Auflage
Wiley-VCH (Verlag)
978-3-527-30759-3 (ISBN)

Infos

In this book, the modelling of dynamic biological engineering processes is presented in a highly understandable way using the unique combination of simplified fundamental theory and direct hands-on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples supplied on a CD-ROM illustrate almost every aspect of biological engineering science. Each example is described in detail, including the model equations. The programms are written in the modern user-friendly simulation language Berkeley Madonna, which can be run on both Windows PC and Power-Macintosh computers.

Madonna solves models comprising many ordinary differential equations using very simple programming, including arrays. It is so powerful that the model parameters may be defined as "sliders", which allow the effect of their change on the model behavior to be seen almost immediately. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be seen simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance.

The extensive experience of the authors, both in university teaching and international courses, is reflected in this well-balanced presentation, which is suitable for the teacher, the student, the biochemist or the engineer.

Inhalt

PART I PRINCIPLES OF BIOREACTOR MODELLING
MODELLING PRINCIPLES
Fundamentals of Modelling
Development and Meaning of Dynamic Differential Balances
Formulation of Balance Equations
BASIC BIOREACTOR DESIGN
Information Inputs
Bioreactor Operations
BIOLOGICAL KINETICS
Enzyme Kinetics
Simple Microbial Kinetics
Structured Kinetic Models
BIOREACTOR MODELLING
General Balances for Tank-type Biological Reactors
Modelling Tubular Plug Flow Bioreactors
MASS TRANSFER
Mass Transfer in Biological Reactors
Interphase Gas-Liquid Mass Transfer
General Oxygen Balances for Gas-Liquid Transfer
Models for Oxygen in Large Scale Bioreactors
DIFFUSION AND BIOLOGICAL REACTION IN IMMOBILIZED BIOCATALYST SYSTEMS
External Mass Transfer
Internal Diffusion and Reaction within Biocatalysts
AUTOMATIC BIOPROCESS CONTROL FUNDAMENTALS
Elements of Feedback Control
Types of Controller Action
Controller Tuning
Advanced Control Strategies
Concepts for Bioprocess Control
REFERENCES
PART II DYNAMIC BIOPROCESS SIMULATION EXAMPLES AND THE BERKELEY MADONNA SIMULATION LANGUAGE
SIMULATION EXAMPLES OF BIOLOGICAL REACTION PROCESSES USING BERKELEY MADONNA
Introductory Examples
Batch Reactors
Fed Batch Reactors
Continuous Reactors
Oxygen Uptake Systems
Controlled Reactors
Diffusion Systems
Multi-Organism and Structured Models
Animal Cell Reactor Examples
APPENDIX: USING THE BERKELEY MADONNA LANGUAGE

Produkt-Details

• Sprache: englisch
• Maße: 170 x 240 mm
• Gewicht: 1166 g
• Einbandart: gebunden
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Biochemie • Biotechnologie • CD-Rom • Computersimulation • Hardcover, Softcover / Biologie • Hardcover, Softcover / Chemie • HC/Biologie • HC/Biologie/Genetik, Gentechnik • Modellierung • Modellierung /CD-ROM • Simulation
• ISBN-10: 3-527-30759-1 / 3527307591
• ISBN-13: 978-3-527-30759-3 / 9783527307593
• Zustand: Neuware