Pharmaceutical Biocatalysis

Drugs, Genetic Diseases, and Epigenetics

Buch | Hardcover

424 Seiten

2020
Jenny Stanford Publishing (Verlag)
978-981-4877-14-5 (ISBN)

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Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

Peter Grunwald studied chemistry at the Universities of Saarbrücken and Hamburg, Germany. He graduated in the field of high-frequency spectroscopy and then became a staff member of the Institute of Physical Chemistry. After receiving his PhD in physical chemistry, he founded a biotechnology research group. He was appointed professor in 2001.

Fermentative Production of Vitamin B6. Exploring Alternative Taxol Sources: Biocatalysis of 7-β-Xylosyl-10-Deacetyltaxol and Application for Taxol Production. Molecular Farming through Plant Engineering: A Cost Effective Approach to Produce Therapeutic and Prophylactic Proteins. Microbial Biotransformations in the Production and Degradation of Fluorinated Pharmaceuticals. Successful Screening of Potent Microorganisms Producing L-Asparaginase. Biotransformation of Xenobiotics in Living Systems. Degradation of Pharmaceutically Active Compounds by White-Rot Fungi and Their Ligninolytic Enzymes. Removal of Pharmaceutical Pollutions from Municipal Sewage Mediated by Laccases. Mechanism of Drug Resistance in Staphylococcus aureus and Future Drug Discovery. Genome Editing and Gene Therapies: Complex and Expensive Drugs. Epigenetic and Metabolic Alterations in Cancer Cells: Mechanisms and Therapeutic Approaches.

Erscheinungsdatum	16.01.2021
Reihe/Serie	Jenny Stanford Series on Biocatalysis
Zusatzinfo	23 Tables, black and white; 18 Illustrations, color; 48 Illustrations, black and white
Sprache	englisch
Maße	152 x 229 mm
Gewicht	980 g
Themenwelt	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Pharmazie ► PTA / PKA
	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	981-4877-14-X / 981487714X
ISBN-13	978-981-4877-14-5 / 9789814877145
Zustand	Neuware