B Cells in Immunity and Tolerance

Buch | Hardcover

181 Seiten

2020 | 1st ed. 2020
Springer Verlag, Singapore
978-981-15-3531-4 (ISBN)

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This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.

Dr. Ji-Yang Wang is a professor at Department of Immunology, School of Basic Medical Sciences, Fudan University, China. He was recruited to the 1000Talents Program of Shanghai in 2013. Prof. Wang’s research focuses on B cell development, activation and differentiation, and B cell-related diseases. He has published more than 100 articles on international journals in these fields.

B cell development and maturation.- B cell receptor signalling.- Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger.- Germinal center reaction.- Memory B cells in local and systemic sites.- Regulation of plasma cell differentiation.- Regulation of humoral immune responses and B cell tolerance by the IgM Fc receptor.- Regulatory B cells.- Diversified IgA-bacteria interaction in gut homeostasis.- Primary antibody deficiencies.- B cell-mediated autoimmune diseases.- B cell lymphomas.

Erscheinungsdatum	04.05.2020
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1254
Zusatzinfo	30 Illustrations, color; 5 Illustrations, black and white; XII, 181 p. 35 illus., 30 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	antibodies • Autoimmune diseases • B Cell • B cell malignancies • cell differentiation • Germinal center reaction • Primary antibody deficiencies • Signaling regulation
ISBN-10	981-15-3531-0 / 9811535310
ISBN-13	978-981-15-3531-4 / 9789811535314
Zustand	Neuware