Role of the Choroid Plexus in Health and Disease

Jeppe Praetorius, Bonnie Blazer-Yost, Helle Damkier (Herausgeber)

Buch | Hardcover

287 Seiten

2020 | 1st ed. 2020
Springer-Verlag New York Inc.
978-1-0716-0535-6 (ISBN)

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This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue.

Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in thechoroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.

Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

Jeppe Praetorius Department of Biomedicine Aarhus University Aarhus Denmark Bonnie Blazer-Yost Department of Biology Indiana University – Purdue University Indianapolis Indianapolis Indiana USA Helle Damkier Department of Biomedicine Aarhus University Aarhus Denmark

Structure of the Mammalian Choroid Plexus.- Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics.- A Frog Model for CSF Secretion.- Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals.- The Signiﬁcance of the Choroid Plexus for Cerebral Iron Homeostasis.- Acid/Base Transporters in CSF Secretion and pH Regulation.- TRPV4, a Regulatory Channel in the Production of Cerebrospinal Fluid by the Choroid Plexus.- Neuroprotective Mechanisms at the Blood-CSF Barrier of the Developing and Adult Brain.- Roles of the Choroid Plexus in Aging.- Choroid Plexus Tumors.- Roles of the Choroid Plexus in CNS Infections.- Hydrocephalus.

Erscheinungsdatum	27.04.2020
Reihe/Serie	Physiology in Health and Disease
Zusatzinfo	46 Illustrations, color; 19 Illustrations, black and white; VI, 287 p. 65 illus., 46 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	1-0716-0535-6 / 1071605356
ISBN-13	978-1-0716-0535-6 / 9781071605356
Zustand	Neuware