Dual Specificity Phosphatases

From Molecular Mechanisms to Biological Function

Rafael Pulido, Roland Lang (Herausgeber)

Buch | Softcover

240 Seiten

2019
MDPI (Verlag)
978-3-03921-688-8 (ISBN)

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Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.

Erscheinungsdatum	22.12.2019
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	Asthma • astrocytes • atypical dual-specificity phosphatases • atypical DUSP • BDNF • brain metastasis • Cancer • Cannabinoids • circulating tumor cells (CTCs) • COPD • Cpp1 • cytokines • DEPArray • Differentiation • dual-specificity phosphatase • dual-specificity phosphatases • DUSP10 • DUSP-4 • E. coli infection • fungal MKPs • granule neurons • HDAC6 (histone deacetylase isoform 6) • hematopoietic cells • HER2 • hypertriglyceridemia • inflammation • Influenza • integrated omics analysis • liver steatosis • macrophage • Macrophages • MAPK • MAP Kinase Phosphatase-2 • MAP kinase phosphatases • MAP Kinases • MAPK phosphatase • MAPKs • microtubules • mitogen-activated protein kinase • Mkp-1 • MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) • Msg5 • N/A • neuroblastoma • Neuronal differentiation • nucleotide receptors • P2X7 • P2Y13 • Pmp1 • Post-translational modification • Proliferation • Protein stability • pseudophosphatase • Respiratory viruses • Rhinovirus • RSV • Sdp1 • Sepsis • Signaling • Single cell analysis • T Cell • TLR Signaling • triple-negative breast cancer (TNBC) • Ubiquitination
ISBN-10	3-03921-688-0 / 3039216880
ISBN-13	978-3-03921-688-8 / 9783039216888
Zustand	Neuware