Radiotracers in Drug Development
Seiten
2019
CRC Press (Verlag)
978-0-367-45372-5 (ISBN)
CRC Press (Verlag)
978-0-367-45372-5 (ISBN)
A unique reference and training aid that meets the essential needs of every drug metabolism department or drug metabolism research team, this book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving across biology, chemistry, and physics, this interdisciplinary resource explains how to employ r
Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.
The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.
A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.
Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.
The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.
A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.
Graham Lappin, Simon Temple
Radiotracers and Drug Registration. Radioactivity and Radiotracers. The Study of Drug Metabolism Using Radiotracers. DNA Binding, Isotope Dilution, and Other Uses of Radiotracers. Quantitative Whole-Body Autoradiography (QWBA). Scintillation Counting. Statistics in Liquid Scintillation Counting. Instrumentation for Detection of Radioactivity. Sample Preparation for Liquid Scintillation Counting. Biomedical Accelerator Mass Spectrometry. Positron Emission Tomography. Gamma Scintigraphy and SPECT.
| Erscheinungsdatum | 16.12.2019 |
|---|---|
| Verlagsort | London |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 453 g |
| Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Radiologie | |
| Naturwissenschaften ► Biologie | |
| Technik | |
| ISBN-10 | 0-367-45372-X / 036745372X |
| ISBN-13 | 978-0-367-45372-5 / 9780367453725 |
| Zustand | Neuware |
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