Imaging Technologies and Transdermal Delivery in Skin Disorders (eBook)

Chenjie Xu, Xiaomeng Wang, Manojit Pramanik (Herausgeber)

eBook Download: PDF

2019 | 1. Auflage
504 Seiten
Wiley-VCH Verlag GmbH & Co. KGaA
978-3-527-81466-4 (ISBN)

Infos

Provides the latest information on imaging technologies and transdermal delivery in skin disorders

This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work.

Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical presentations, pathophysiological mechanisms, and current clinical practices used to treat diseases affecting the skin are then introduced. Common preclinical models used for studying the mechanisms of diverse skin diseases, validation of novel therapeutic targets, and screening of new drugs to treat these diseases are also covered. The book examines the latest imaging technologies for understanding in vivo skin changes, as well as technologies such as high-resolution ultrasound imaging, quantitative Magnetic Resonance Imaging, high-resolution Optical Coherence Tomography, and emerging hybrid-imaging modalities. It concludes with chapters introducing emerging drug delivery technologies and potential future innovative developments.

* Presents up-to-date knowledge of the skin biology and pathologies
* Introduces advancements in the topic of imaging technology for tracing the drug delivery process, which is rarely systematically reported by other counterparts
* Covers the latest development in three inter-related directions of drug delivery, imaging, and skin disease intersect for skin research
* Provides an overview of the latest development of diagnostic and therapeutic technologies for skin diseases
Imaging Technologies and Transdermal Delivery in Skin Disorders will be of great interest to analytical chemists, materials scientists, pharmaceutical chemists, clinical chemists, biotechnologists, bioengineers, cosmetics industry, and dermatologists.

Autor

Dr. Chenjie Xu is an assistant professor at School of Chemical and Biomedical Engineering (SCBE) at Nanyang Technological University (NTU), Singapore. He received his PhD. (2009) from Brown University under Prof. Shouheng Sun and did his postdoc under Prof. Jeffrey Karp at Brigham and Women's Hospital. He is interested in developing transdermal technologies for diagnosis and treatment of skin diseases especially abnormal scar. He has published more than 90 peer-reviewed articles. Dr. Xiaomeng Wang currently serves as an Assistant Professor at NTU, Principal Investigator at IMCB, Honorary Lecturer at UCL, Adjunct Research Scientist at SERI. She is an innovative scientist with extensive expertise in the field of vascular biology pertaining to diseases of the skin. Her recent study led to the identification of a novel angiogenic factor, LRG1 and the LRG1 blocking antibody is currently in Phase I clinical trial as a combined treatment strategy with Lucentis in patients with neovascular AMD. Her current research focuses on the role of LRG1 in fibrovascular proliferation and scaring of the skin and her work had been published in high impact journals including Nature and Nature protocols. Over the last few years, her laboratory has established and developed a number of state-of-the-art in vitro, ex vivo, in vivo assay systems that are suitable for detailed characterization of the temporal and spatial interactions between different types of cells involved in sprouting angiogenesis and tissue fibrosis. Dr. Wang is also the co-inventor on two international patents relating to LRG1 and its potential as therapeutic target for vasoproliferative conditions and cancer Dr. Manojit Pramanik received his Ph.D. degree (2010) in Biomedical Engineering from Washington University in St. Louis, St. Louis, USA under the tutelage of Dr. Lihong Wang. He joined the School of Chemical and Biomedical Engineering (SCBE) at Nanyang Technological University (NTU), Singapore as Assistant Professor in January 2014. He obtained his masters (M.Tech.) degree from Department of Instrumentation at Indian Institute of Science (IISc), Bangalore, India in 2004. He did his undergraduate (B.Tech) from the Department of Electrical Engineering at Indian Institute of Technology (IIT), Kharagpur, India in 2002. Prior to joining NTU he served as Assistant Professor in the Department of Electrical Engineering at Indian Institute of Science (IISc), Bangalore, India for one and half years. His industry experiences include two years at General Electric Global Research (GRC), Bangalore, India and one year at Philips Medical System, Bangalore, India. He is the recipient of Department of Atomic Energy (DAE), Government of India Young Scientist Research Award 2013. His research interest include development of photoacoustic and thermoacoustic imaging systems, image reconstruction methods, clinical application areas such as breast cancer imaging, molecular imaging, contrast agent development, monte-carlo simulation for light transport in biological tissue etc. He has more than 100 international journal and conference publications and presentations.

Inhalt

CHAPTER 1: SKIN STRUCTURE AND BIOLOGY
CHAPTER 2: WOUND HEALING AND ITS IMAGING
CHAPTER 3: COMMON SKIN DISEASES - CHRONIC INFLAMMATORY AND AUTOIMMUNE DISORDERS
CHAPTER 4: COMMON SKIN DISEASES - AUTOIMMUNE BLISTERING DISORDERS
CHAPTER 5: COMMON SKIN DISEASES -SKIN CANCER
CHAPTER 6: PRECLINICAL MODELS FOR DRUG SCREENING AND TARGET VALIDATION
CHAPTER 7: SKIN TISSUE ENGINEERING WITH NANOSTRUCTURED MATERIALS
CHAPTER 8: TOPICAL/TRANSDERMAL DELIVERY WITH CHEMICAL ENHANCERS AND NANOPARTICLES
CHAPTER 9: NEEDLE FREE JET INJECTORS FOR DERMAL AND TRANSDERMAL DELIVERY OF ACTIVES
CHAPTER 10: MICRONEEDLES FOR TRANSDERMAL DRUG DELIVERY
CHAPTER 11: ULTRASOUND ENHANCED TRANSDERMAL DRUG DELIVERY
CHAPTER 12: IONTOPHORESIS ENHANCED TRANSDERMAL DRUG DELIVERY
CHAPTER 13: ULTROSOUND IMAGING IN DERMATOLOGY
CHAPTER 14: QUANTITATIVE MAGNETIC RESONANCE IMAGING OF THE SKIN: IN VITRO AND IN VIVO APPLICATIONS
CHAPTER 15: HIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY (oct) FOR SKIN IMAGING
CHAPTER 16: PHOTOACOUSTIC IMAGING OF SKIN
CHAPTER 17: LASER SPECKLE TECHNIQUES FOR FLOW MONITORING IN SKIN

Produkt-Details

• Erscheint lt. Verlag: 11.12.2019
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Bioanalytical Chemistry • Bioanalytische Chemie • Chemie • Chemistry • Drug Formulation & Delivery • nanomedicine • Nanomedizin • Nanotechnologie • nanotechnology • Wirkstoffformulierung, Wirkstofftransport
• ISBN-10: 3-527-81466-3 / 3527814663
• ISBN-13: 978-3-527-81466-4 / 9783527814664