Recent Progress in Solid Dispersion Technology

Buch | Softcover

204 Seiten

2019
MDPI (Verlag)
978-3-03921-501-0 (ISBN)

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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Erscheinungsdatum	10.10.2019
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	accelerated stability test • amorphisation • Amorphous • amorphous polymeric salt • amorphous solid dispersion • amorphous solid dispersions • Anticancer drugs • Ball milling • bicaludamide • Bioavailability • characterization • Ciprofloxacin • classification • Continuous processing • crystallization • crystallization tendency • Dissolution • dissolution enhancement • Dissolution rate • Enrofloxacin • evaporation • Granulation • hot melt extrusion • interaction • intrinsic dissolution rate • Manufacturing Methods • mesoporous • Milling • miscibility • Molecular Complex • Molecular Dynamics Simulation • nanoaggregates • nucleation • Pharmaceutical glass • Phase diagram • Poloxamer • polyelectrolyte excipient matrix • Polyelectrolytes • Polymer • poorly soluble drugs • process development • rebamipide • Self-Assembly • solid dispersion • solid dispersions • Solubility • Solubility enhancement • spectroscopic techniques • Spray Drying • stability • Tadalafil • Thermal Analysis • Thermodynamic modeling • Weibull dissolution model • Wood’s apparatus
ISBN-10	3-03921-501-9 / 3039215019
ISBN-13	978-3-03921-501-0 / 9783039215010
Zustand	Neuware