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Translational ADMET for Drug Therapy – Principles, Methods, and Pharmaceutical Applications

SB Yanni (Autor)

Software / Digital Media
352 Seiten
2015
John Wiley & Sons Inc (Hersteller)
978-1-118-83844-0 (ISBN)
CHF 178,50 inkl. MwSt
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Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools for drug discovery and development, with new translational approaches to clinical drug investigations in various human populations.

Illustrates ADME properties, from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations
Provides examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage
Presents successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines
Offers a hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies
Includes discussion of IND / NDA filing and drug labeling to support drug registration and approval

Souzan B. Yanni, PhD, is Founder and President of DMPK Consultants, Inc., which leads ADME/PK in support of preclinical and clinical investigations for of pharmaceutical and biotech companies. She has over 20 years of hands-on leadership experience in planning, executing, and overseeing drug discovery and early development for therapeutic programs with national and international pharmaceutical companies, biotech groups, and CROs. Dr. Yanni possesses a PhD in Pharmaceutical Sciences, MS in Biochemistry, and BS in Chemistry. She is the author of several peer-reviewed articles, review articles, and book chapters on ADMET/PK as well as an external reviewer / editor for other journals.

Erscheint lt. Verlag 12.10.2015
Verlagsort New York
Sprache englisch
Maße 150 x 250 mm
Gewicht 666 g
Themenwelt Naturwissenschaften Biologie
Naturwissenschaften Chemie
ISBN-10 1-118-83844-0 / 1118838440
ISBN-13 978-1-118-83844-0 / 9781118838440
Zustand Neuware
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