Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Raphael Enoque Ferraz de Paiva (Autor)

Buch | Softcover

XXXIX, 151 Seiten

2019 | 1. Softcover reprint of the original 1st ed. 2018
Springer International Publishing (Verlag)
978-3-030-13150-0 (ISBN)

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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling.

Au(I)-phosphine series design.- Probing the Protein: Ion Mobility Spectrometry.- Probing Gold: X-ray Absorption Spectroscopy.- Probing Cells: Cytotoxicity Evaluation.- Au(III) series with k²C,N and k²N,N' ligands.- "Dual Probe" X-ray Absorption Spectroscopy.

Erscheinungsdatum	25.10.2019
Reihe/Serie	Springer Theses
Zusatzinfo	XXXIX, 151 p. 100 illus., 38 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	302 g
Themenwelt	Naturwissenschaften ► Chemie ► Anorganische Chemie
Schlagworte	Citotoxicity • Gold Complexes • HIV-1 Nucleocapsid • Human Trabscription Factor Protein 1 Sp1 • Nucleocapsid Protein NCp7 • Protein-Ligand Interactions • Travelling-Wave Ion Mobility Mass Spectrometry • X-ray absorption spectroscopy • Zinc Finger Proteins
ISBN-10	3-030-13150-5 / 3030131505
ISBN-13	978-3-030-13150-0 / 9783030131500
Zustand	Neuware