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Toxoplasma Gondii

The Model Apicomplexan Perspectives and Methods

Buch | Hardcover

1242 Seiten

2020 | 3rd edition
Academic Press Inc (Verlag)
978-0-12-815041-2 (ISBN)

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Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center. Dr. Kami Kim is a physician-scientist who joined the USF faculty in 2017 as a Professor of Internal Medicine (Infectious Diseases and International Medicine) and Professor of Global Health. Her laboratory focuses upon understanding the pathogenesis of toxoplasmosis and malaria, parasitic diseases of global significance. The Toxoplasma projects use a multidisciplinary systems biology approach to understand how the parasite senses and responds to changes in its host. Using a combination of epigenomics, genetics and proteomics, her group is studying how the parasite transitions from the pathogenic tachyzoite form to the persistent bradyzoite form. She is investigating the epigenetic and genetic factors that govern the host response to parasites. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America as well as an elected member of the Association for American Physicians and the American Society for Clinical Investigation.

1. The History and Life Cycle of Toxoplasma gondii
2. The Ultrastructure of Toxoplasma gondii
3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
4. Human Toxoplasma Infection　
5. Ocular Disease due to Toxoplasma gondii
6. Toxoplasmosis in Wild and Domestic Animals
7. Toxoplasma Animal Models and Therapeutics
8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition
9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism
10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics
11. The Apicoplast and Mitochondrion of Toxoplasma gondii
12. Calcium Storage and Homeostasis in Toxoplasma gondii
13. Signaling Networks in Toxoplasma gondii
14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)
15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy
16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)
17. Toxoplasma Host Effectors in Cell Interactions
18. Bradyzoite and Sexual Stage Development
19. Development and Application of Classical Genetics in Toxoplasma gondii
20. Genetic Manipulation of Toxoplasma gondii
21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii
23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences
25. Innate Immunity to Toxoplasma gondii
26. Adaptive Immunity and Genetics of the Host Immune Response

Erscheinungsdatum	01.04.2020
Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	2650 g
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	0-12-815041-6 / 0128150416
ISBN-13	978-0-12-815041-2 / 9780128150412
Zustand	Neuware