Tau Biology
Springer Verlag, Singapore
978-981-329-357-1 (ISBN)
Akihiko Takashima Gakushuin University, Dept Life Sci., Lab Alzheimers Dis., Japan Benjamin Wolozin Boston University, School of Med., Dept Pharmacol., USA Luc Buee University of Lille, CHU Lille, INSERM, Memory & Resources Res. Ctr., France
1) Structure and role of Tau molecule.- (1) Tau structure in solution: FRET study.- (2) Tau structure in solution: NMR study.- (3) Structure of NFT: Biochemical approach.- (4) Structure of NFT: CryoEM approach.- (5) MAPT tau gene and FTDP-17 mutation.- (6) Tau phosphorylation.- (7) Tau acetylation.- (8) Tau truncation.- (9) Tau interacted proteins: interactome.- (10) Tau clearance mechanism.- 2) Tau localization and function.- (11) Localization of Tau.- (12) Axonal transport.- (13) Synaptic localization of tau.- (14) Role of tau in synapse.- (15) Tau in nucleus and nucleic acids.- (16) Tau and the translational stress response.- 3) Tauopathies; pathology, drivers, and marker.- (17) Tau pathology with aging.- (18) Clinical symptom and pathology of FTD including FTDP-17.- (19) Chronic Traumatic Encephalopathy.- (20) Myotonic dystrophies.- (21) Tau PET.- (22) Tau PET/connectome/fMRI.- (23) Stress.- (24) Diabetes.- (25) Relationship between ApoE and tau.- (26) Relationship between Ab and tau.- 4) Tau aggregation, and therapy.- (27) Tau Oligomer.- (28) Tau droplet formation.- (29) Stress granule.- (30) Tau secretion.- (31) Tau seeding.- (32) Prion-like Tau propagation.- (33) Experimental models for tauopathies.- (34) Dementia therapy targeting tau.- (35) Tau aggregation inhibitor.
Erscheinungsdatum | 28.02.2020 |
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Reihe/Serie | Advances in Experimental Medicine and Biology ; 1184 |
Zusatzinfo | 75 Illustrations, color; 8 Illustrations, black and white; XI, 416 p. 83 illus., 75 illus. in color. |
Verlagsort | Singapore |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Naturwissenschaften ► Biologie ► Zoologie | |
ISBN-10 | 981-329-357-8 / 9813293578 |
ISBN-13 | 978-981-329-357-1 / 9789813293571 |
Zustand | Neuware |
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