Parkinson's Disease

Genetics and Pathogenesis

Buch | Softcover

404 Seiten

2019
CRC Press (Verlag)
978-0-367-38915-4 (ISBN)

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An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson’s Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. The book reviews the major aspects of the disease including motoric and pathologic features, autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations. It also provides an in-depth review of genetic considerations. With contributions by recognized experts on the topic, emphasis is placed on pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.

Ted M. Dawson

OVERVIEW. Neuropathology and Staging of Parkinson's Disease. Genetics of Parkinson's Disease. Epidemiology of Parkinson's Disease. Treatment of Parkinson's Disease. GENETICS. Genetics of Alpha-Synuclein. Clinical and Genetic Features of PARKIN-Related Parkinson's Disease. DJ-1 in Parkinson's Disease. PINK1 Parkinsonism. LRRK2. Genetics of Tau in Parkinsonism. Genetic Risk Factors for PD.
PATHOGENESIS. Alpha-Synuclein and Parkinson's Disease. Tau in Parkinson's Disease.
The Role of PARKIN in Parkinson's Disease. Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis. The Ubiquitin-Proteasome System in Parkinson's Disease. ANIMAL MODELS. Transgenic Models of Alpha-Synucleinopathy. Mouse Models of Recessive Parkinsonism. Drosophila Models of Parkinson's Disease. C. Elegans Models of Parkinson's Disease. The MPTP Model of Parkinson's Disease. Rotenone Model. Drug Trials in Animal Models of PD

Erscheinungsdatum	30.09.2019
Verlagsort	London
Sprache	englisch
Maße	152 x 229 mm
Gewicht	766 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	0-367-38915-0 / 0367389150
ISBN-13	978-0-367-38915-4 / 9780367389154
Zustand	Neuware