Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents (eBook)

Sadik Mejid (Autor)

eBook Download: PDF

2019 | 1. Auflage
9 Seiten
GRIN Verlag
978-3-668-96106-7 (ISBN)

Infos

Presentation slides from the year 2014 in the subject Chemistry - General, grade: 1,3, University of Cologne (Anorganische Chemie), language: English, abstract: Seminar Presentation in the subject "Inorganic Chemistry" with the title "Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents". With the following contents:
-The problems of the currently used anticancer drugs;
- Palladium derivatives as an alternative to Platinum-based compounds;
- The first Water-Soluble Iminophosphorane Ligand;
- Preparation of Water-Soluble Ligand 1;
- Stability of Compounds in Solution;
- Cytotoxicity IC50 (μM) of Cisplatin, Ligand 1, Phosphine Oxide, TPA=O, and Metal Complexes 2-8 in Human cell lines;
- The Annexin V Binding Assay;
- Activity of Compounds 2 or 3 (50 μM) and Cisplatin against apoptosis-resistent cells;
- Chromosomal DNA and Plasmid DNA;
- Interactions of 2 and 3 with Plasmid DNA Using Electroforesis Mobility Shift Assay (EMSA);
- Interaction with Human Serum Albumin;
- Stern-Volmer plot for quenching with ligand 1 and compounds 2, 3, and 5 – 8 and cisplatin;
- Advantage over Cisplatin;
- Summery

Produkt-Details

• Erscheint lt. Verlag: 19.6.2019
• Verlagsort: München
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Allgemeines / Lexika
• Schlagworte: Agents • Anticancer • Complexes • iminophosphorane • Ligand • Organometallic • Palladium • Potential • water-soluble
• ISBN-10: 3-668-96106-9 / 3668961069
• ISBN-13: 978-3-668-96106-7 / 9783668961067