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Developmental Origins of Health and Disease (DOHaD) -

Developmental Origins of Health and Disease (DOHaD)

From Biological Basis to Clinical Significance

Takeo Kubota, Hideoki Fukuoka (Herausgeber)

Buch | Softcover
95 Seiten
2019 | Softcover reprint of the original 1st ed. 2018
Springer Verlag, Singapore
978-981-13-3856-4 (ISBN)
CHF 239,65 inkl. MwSt
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This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

Takeo Kubota Faculty of Child Studies, Seitoku University, Chiba, Japan Hideoki Fukuoka Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Part 1 Biological Basis.- One carbon metabolism and lipid metabolism in DOHaD.- Novel models of epigenetic gene regulation in the nutritional environment.- Epigenetic switching and neonatal nutritional environment.- Part 2 Disease and environment.- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD).- Fetal origins of hypertension.- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory.- Part 3 Transgenerational mechanism and its consequences.- Placental development and nutritional environment.- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm.- Part 4 Clinical Significance.- Preemptive epigenetic medicine based on fetal programming.

Erscheint lt. Verlag 5.2.2019
Reihe/Serie Advances in Experimental Medicine and Biology ; 1012
Zusatzinfo 16 Illustrations, color; 7 Illustrations, black and white; VII, 95 p. 23 illus., 16 illus. in color.
Verlagsort Singapore
Sprache englisch
Maße 178 x 254 mm
Themenwelt Studium 1. Studienabschnitt (Vorklinik) Histologie / Embryologie
Studium 1. Studienabschnitt (Vorklinik) Physiologie
Naturwissenschaften Biologie Genetik / Molekularbiologie
Schlagworte epigenome • Maternal under-nutrition • Metabolic disease • Nutritional environment • Pre-emptive medicine
ISBN-10 981-13-3856-6 / 9811338566
ISBN-13 978-981-13-3856-4 / 9789811338564
Zustand Neuware
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