Persister Cells and Infectious Disease

Kim Lewis (Herausgeber)

Buch | Hardcover

X, 295 Seiten

2019 | 1st ed. 2019
Springer International Publishing (Verlag)
978-3-030-25240-3 (ISBN)

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This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.

Professor Kim Lewis, Northeastern University Boston, Massachusetts, USA

1. Evolution under antibiotic treatments: interplay between antibiotic persistence, tolerance and resistance.- 2. Antibiotic persisters and relapsing Salmonella enterica infections.- 3. The Biology of Persister Cells in E. coli.- 4. Persister Formation and Antibiotic Tolerance of Chronic Infections.- 5. Persister formation driven by TisB-dependent membrane depolarization.- 6. Toxin-antitoxin systems and persistence.- 7. Nutrient depletion and bacterial persistence.- 8. Genetic determinants of persistence in Escherichia coli.- 9. Persister resuscitation.- 10. Host-pathogen interactions influencing Mycobacterium tuberculosis persistence and drug tolerance.- 11. Drug susceptibility of individual mycobacterial cells.- 12. Antimicrobial drug discovery against persisters.

Erscheinungsdatum	28.11.2019
Zusatzinfo	X, 295 p. 34 illus., 28 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	619 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	antibiotic resistance • bacterial persistence • dormant cells • drug resistance • drug tolerance • host immunity • Infectious Diseases • subpopulation
ISBN-10	3-030-25240-X / 303025240X
ISBN-13	978-3-030-25240-3 / 9783030252403
Zustand	Neuware