Exploring Life Phenomena with Statistical Mechanics of Molecular Liquids

Fumio Hirata (Autor)

Buch | Hardcover

312 Seiten

2020
CRC Press (Verlag)
978-1-138-56388-9 (ISBN)

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In a living body, a variety of molecules are working in a concerted manner to maintain its life, and to carry forward the genetic information from generation to generation. A key word to understand such processes is "water," which plays an essential role in life phenomena. This book sheds light on life phenomena, which are woven by biomolecules as warp and water as weft, by means of statistical mechanics of molecular liquids, the RISM and 3D-RISM theories, both in equilibrium and non-equilibrium. A considerable number of pages are devoted to basics of mathematics and physics, so that students who have not majored in physics may be able to study the book by themselves. The book will also be helpful to those scientists seeking better tools for the computer-aided-drug-discovery.

Explains basics of the statistical mechanics of molecular liquids, or RISM and 3D-RISM theories, and its application to water.
Provides outline of the generalized Langevin theory and the linear response theory, and its application to dynamics of water.
Applies the theories to functions of biomolecular systems.
Applies the theories to the computer aided drug design.
Provides a perspective for future development of the method.

Fumio Hirata has completed his PhD from Hokkaido University and postdoctoral studies from State University of New York, University of Texas, and Rutgers University. He was an associate professor in Kyoto University, and a professor in Institute for Molecular Science (IMS). He is currently a fellow of Toyota Riken (Toyota Physical and Chemical Institute), and a professor emeritus of IMS. He has published more than 200 papers in reputed journals, and authored and edited several books, including Molecular Theory of Solvation (Kluwer, 2013).

General Introduction. Fundamentals: Basic Concepts Related to Statistical Mechanics. Statistical Mechanics of Liquid and Solutions. Dynamics of Liquids and Solutions. Theory of Biomolecular Solvation and Molecular Recognition. Structural Fluctuation and Dynamics of Protein in Aqueous Solutions. Applications of the Theories to In-silico Drug Discovery. References. Epilogue.

Erscheinungsdatum	25.02.2020
Zusatzinfo	15 Tables, black and white; 26 Illustrations, color; 68 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	178 x 254 mm
Gewicht	784 g
Themenwelt	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Technik
ISBN-10	1-138-56388-9 / 1138563889
ISBN-13	978-1-138-56388-9 / 9781138563889
Zustand	Neuware