Mitochondria in Health and in Sickness

Buch | Hardcover

277 Seiten

2019 | 1st ed. 2019
Springer Verlag, Singapore
978-981-13-8366-3 (ISBN)

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Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondriain host-pathogen interactions.

Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

Prof. Andrea Urbani has been involved in structural and functional investigation of integral membrane protein complexes of the respiratory chains since he moved in 1998 to Heidelberg (Germany) at the European Molecular Biology Laboratory (EMBL) in the Structural Biology Program. Mass spectrometry characterisation and identification of proteins and metabolites represents the primary motive of the laboratories he has established during the last fifteen years. He is currently the Director of the Biochemistry and Clinical Biochemistry Institute of the Catholic University of the Sacred Heart, and President of the European Proteomics Association (EuPA) for the years 2015-2019. Prof. Mohan Babu is internationally recognized as an emerging leader in network biology, and a pioneer for mapping epistatic relationships and membrane-associated protein complexes in prokaryotes. His multidisciplinary research program focuses on characterizing protein and genetic interaction networks from microbes to mammals, and establishing new molecular mechanisms for mitochondrial proteins associated with neurodegenerative disorders. He is an editorial board member of the journal “BioEssays”, editor of the book “Prokaryotic Systems Biology” (Springer), Associate editor of “BMC Microbiology”, secretary treasurer for “Canadian Society of Microbiology”, and an advisory board member of the “International Mitochondrial Human Proteome Initiative”.

Chapter 1. Mitochondrial Metabolism in Cancer. A Tangled Topic. Which Role for Proteomics? (Roberto Scatena).- Chapter 2. Mitochondrial Proteins in the Development of Parkinson's Disease (Mauro Fasano and Tiziana Alberio).- Chapter 3. Role of Mitochondria in Host-Pathogen Interaction (Alessio Soggiu).- Chapter 4. Mitochondria Lysine Acetylation and Phenotypic Control (Federica Ciregia).- Chapter 5. Crosstalk Between Oxidative Stress and Mitochondrial Damage: Focus on Amyotrophic Lateral Sclerosis (Viviana Greco).- Chapter 6. A Tag-Based Affinity Purification Mass Spectrometry Workflow for Systematic Isolation of the Human Mitochondrial Protein Complexes (Zhuoran Wu).- Chapter 7. Targeted Proteomics to Study Mitochondrial Biology (Rainer Bischoff and Karin Wolters).- Chapter 8. Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics (Walid Houry).- Chapter 9. Investigating the Role of Mitochondria in Type 2 Diabetes – Lessons from Lipidomics and Proteomics Studies of Skeletal Muscle and Liver (Albert Sickmann).- Chapter 10. Quantification of Mitochondrial Network Characteristics in Health and Disease (Jeff Stuart).- Chapter 11. Cysteine Switches and the Regulation of Mitochondrial Bioenergetics and ROS Production (Ryan Mailloux).- Chapter 12. Advances Towards Therapeutic Approaches for mtDNA Disease (Timothy Shutt).- Chapter 13. Mitochondrial Genetics (Vanessa Goncalves).- Chapter 14. Heteroplasmy Shifting as Therapy for Mitochondrial Disorders (Neal Sondheimer).- Chapter 15. Mitochondrial Function and Dysfunction in Alzheimer’s Disease (Benedict Albensi).- Chapter 16. Application of CRISPR-Cas9 Screening Technologies to Study Mitochondrial Biology in Healthy and Disease States (Steven Chan).

Erscheinungsdatum	20.09.2019
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1158
Zusatzinfo	44 Illustrations, color; 3 Illustrations, black and white; VI, 277 p. 47 illus., 44 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	mitochondrial disease • mitochondrial dysfunction • Mitochondrial health • Mitochondrial metabolism • Mitochondrial proteomics
ISBN-10	981-13-8366-9 / 9811383669
ISBN-13	978-981-13-8366-3 / 9789811383663
Zustand	Neuware