The Nociceptin/Orphanin FQ Peptide Receptor

Mei-Chuan Ko, Girolamo Caló (Herausgeber)

Buch | Hardcover

X, 417 Seiten

2019 | 1st ed. 2019
Springer International Publishing (Verlag)
978-3-030-20185-2 (ISBN)

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The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

PART I. The N/OFQ-NOP Receptor System.- 1. The History of N/OFQ and the NOP Receptor.- 2. NOP-Targeted Peptide Ligands.- 3. NOP-Targeted Nonpeptide Ligands.- 4. Pharmacological Assays for Investigating the NOP Receptor.- 5. Electrophysiological Actions of N/OFQ.- 6. NOP Receptor Signaling Cascades.- 7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor.- PART II. Biological Actions of NOP Ligands.- 8.NOP-Related Mechanisms in Pain and Analgesia.- 9. NOP-Related Mechanisms in Substance Use Disorders.- 10. NOP Receptor Ligands and Parkinson's Disease.- 11. NOP Ligands for the Treatment of Anxiety and Mood Disorders.- 12. The Nociceptin/Orphanin FQ System and the Regulation of Memory.- 13. N/OFQ-NOP System in Food Intake.- 14. N/OFQ-NOP System in Peripheral and Central Immunomodulation.- 15. N/OFQ-NOP System and Airways.- 16. Effects of NOP-Related Ligands in Nonhuman Primates.- PART III. First Clinical Studies with NOP Ligands.- 17. Nociceptin/Orphanin FQ and Urinary Bladder.- 18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors.- 19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094).- 20. Correction to: Electrophysiological Actions of N/OFQ.

Erscheinungsdatum	26.07.2019
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	X, 417 p. 78 illus., 21 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	799 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Schmerztherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	Biological Action • Ligand-Receptor System • Nociceptin/Orphanin FQ Peptide Receptor • NOP • Opioid Receptor • Psychopharmacology • Structure-activity Relationship • therapeutics
ISBN-10	3-030-20185-6 / 3030201856
ISBN-13	978-3-030-20185-2 / 9783030201852
Zustand	Neuware