Behavioral Neurobiology of Psychedelic Drugs

Adam L. Halberstadt, Franz X. Vollenweider, David E. Nichols (Herausgeber)

Buch | Softcover

X, 430 Seiten

2019 | 1. Softcover reprint of the original 1st ed. 2018
Springer Berlin (Verlag)
978-3-662-58563-4 (ISBN)

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This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.

Preface.- Chemistry and structure-activity relationships of psychedelics.- Hallucinogens and serotonin 5-HT2A receptor-mediated signaling pathways.- Effects of hallucinogens on neuronal activity.- Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons.- The effects of hallucinogens on gene expression.- Effect of Hallucinogens on Unconditioned Behavior.- Hallucinogens in Drug Discrimination.- Phenomenology, structure and dynamic of psychedelic states.- Serotonergic hallucinogen-induced visual perceptual alterations.- New world tryptamine hallucinogens and the neuroscience of ayahuasca.- Experimental psychosis research and schizophrenia - similarities and dissimilarities in psychopathology.- A review of Hallucinogen Persisting Perception Disorder (HPPD) and an exploratory study of subjects claiming symptoms of HPPD.- Therapeutic applications of classic hallucinogens.- Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates.

"This book brings together the latest basic and clinical research into the underlying mechanism of action, effects, and possible clinical uses of psychedelic drugs. ... It brings together current knowledge regarding this class of drugs pharmacology, neurobiological effects, subjective experience, and therapeutic effects. ... It brings together preclinical and clinical data, which will be of interest to anyone involved with or curious about this category of drugs." (Michael Easton, Doody's Book Reviews, September, 2018)

“This book brings together the latest basic and clinical research into the underlying mechanism of action, effects, and possible clinical uses of psychedelic drugs. … It brings together current knowledge regarding this class of drugs pharmacology, neurobiological effects, subjective experience, and therapeutic effects. … It brings together preclinical and clinical data, which will be of interest to anyone involved with or curious about this category of drugs.” (Michael Easton, Doody's Book Reviews, September, 2018)

Erscheinungsdatum	25.02.2019
Reihe/Serie	Current Topics in Behavioral Neurosciences
Zusatzinfo	X, 430 p. 196 illus., 158 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	676 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	entactogens • hallucinogens • MDMA • psychedelics • Psychopharmacology • psychotomimetics
ISBN-10	3-662-58563-4 / 3662585634
ISBN-13	978-3-662-58563-4 / 9783662585634
Zustand	Neuware