Dermal Drug Selection and Development
Springer International Publishing (Verlag)
978-3-319-86639-0 (ISBN)
The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the
scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.Lionel Trottet, PhD is a DMPK Unit Manager, Drug Discovery chez Oncodesign in France. He has 20 years of expertise in Dermatology (dermal drug discovery, pharmacokinetics, PK/PD and formulation), 18 years of experience in general pharmacokinetics, drug metabolism and PK/PD, 13 years of experience as a DMPK representative in Drug Discovery projects, and 8 years of experience as a DMPK manager. Howard Maibach, MD is an expert in contact and occupational dermatitis and sees patients at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic at University of California, San Francisco (UCSF). His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders. Dr. Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health. He is a professor in the Department of Dermatology at UCSF.
Introduction.- Choosing the topical drug candidate.- Key factors affecting the efficacy of a topical drug candidate.- Topical vs. Oral/systemic Drug discovery.- Assessing drug concentration in skin.- Assessing Topical efficacy.- Assessing the therapeutic index.- Topical vehicle selection.- Topical drug development strategies.- Topical drug candidate selection criteria and cascade.- Selecting a dermal drug candidate.- Conclusions and perspectives.
"This book provides some valuable insights into the challenges related to the design and development of dermatopharmaceuticals. As such, this book is expected to be well received by the scientific community involved in this kind of research. ... this book should serve as a reference for anyone interested in developing dermatopharmaceuticals. ... Written by an expert in drug delivery, this book provides an overview of challenges the industry faces in selecting and developing a dermal product." (Rahmat M. Talukder, Doody's Book Reviews, September, 2017)
| Erscheint lt. Verlag | 12.8.2018 |
|---|---|
| Zusatzinfo | XVI, 148 p. 53 illus., 35 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 260 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie |
| Medizin / Pharmazie ► Pharmazie | |
| Naturwissenschaften ► Chemie ► Technische Chemie | |
| Technik | |
| Schlagworte | dermal drug candidate selection • dermal drugs • dermal pharmacokinetics • Dermatology • drug development |
| ISBN-10 | 3-319-86639-7 / 3319866397 |
| ISBN-13 | 978-3-319-86639-0 / 9783319866390 |
| Zustand | Neuware |
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