Pharmacology of Mitochondria

Harpreet Singh, Shey-Shing Sheu (Herausgeber)

Buch | Softcover

XI, 493 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-86130-2 (ISBN)

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This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Mitochondrial Genetics and Ion Transportation: Nuclear transcription factors in the mitochondria: a new paradigm in cellular transformation.- The mitochondrial permeability transition pore and ATP synthase.- Mitochondrial ion fluxes in health and diseases.- Mitochondrial anion channels.- Pharmacology of mitochondrial potassium channels.- Mitochondrial Ca2+ uniporter complex as promising therapeutic target for human diseases and aging.- Mitochondria in Health and Diseases: Mitochondrial Division in Human Disease.- Mitochondrial cholesterol and the paradox in cell death.- Mitochondrial dysfunction in neuromuscular disorders.- Mitochondrial dynamics in cancer.- The emerging role of mitochondrial targeting in kidney disease.- Mitochondrial dynamics as therapeutic targets for treating cardiac disease.- Mitochondria in Alzheimer´s disease and Diabetes-associated Neurodegeneration.- Leber Hereditary Optic Neuropathy, a mitochondrial disease unique in many ways.- Therapeutic Approaches and Mitochondria: Mitochondrial Variation in Health and Disease.- Bioinformatic methods and resources for integrated mitochondrial physiology.- Nanoparticle based therapeutics for mitochondrial dysfunctions.- Mitochondrial respiratory chain complexes as drugs targets.- Targeting the Mitoflash for the Control of Mitochondrial Functions.-Mitochondrial Antioxidant Therapy: Promise or Delusion?- Roles of mitochondrial ROS generation to protect from further prooxidant situations.- MITO-Porter for mitochondrial delivery and mitochondrial functional analysis.- Toxicity of antiepileptic drugs to mitochondria.

Erscheint lt. Verlag	10.8.2018
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	XI, 493 p.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	1035 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Calcium • mitochondrial ion channels • mitochondrion • Oxidative stress • pharmacology • Reactive oxygen species
ISBN-10	3-319-86130-1 / 3319861301
ISBN-13	978-3-319-86130-2 / 9783319861302
Zustand	Neuware