Anti-fibrotic Drug Discovery

Jehrod Brenneman, Malliga R Iyer (Herausgeber)

Buch | Hardcover

356 Seiten

2020
Royal Society of Chemistry (Verlag)
978-1-78801-510-3 (ISBN)

Artikel merken

Anti-fibrotic Drug Discovery is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

TGFβ Signaling;

Targeting the αv Integrins in Fibroproliferative Disease;

Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators;

Autotaxin Inhibitors in Fibrosis;

Inhibition of LOXL2 and Other Lysyl Oxidase (Like) Enzymes: Intervention at the Core of Fibrotic Pathology;

Targeting the Ubiquitin Proteasome System in Pulmonary Fibrosis;

Galectin-3 Involvement in Fibrotic Diseases;

Emerging Role of CXCR4 in Fibrosis;

BH3 Mimetic Drugs for Anti-fibrotic Therapy;

Intratumoral Fibrosis: Emerging Concepts and Therapeutic Opportunities;

Targeting Fibroblasts in Fibrosis and Cancer

Erscheinungsdatum	08.01.2019
Reihe/Serie	Drug Discovery ; Volume 73
Verlagsort	Cambridge
Sprache	englisch
Maße	156 x 234 mm
Gewicht	708 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Chemie ► Organische Chemie
ISBN-10	1-78801-510-X / 178801510X
ISBN-13	978-1-78801-510-3 / 9781788015103
Zustand	Neuware