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Emerging Fluorinated Motifs

Synthesis, Properties and Applications

Dominique Cahard, Jun-An Ma (Herausgeber)

Buch | Hardcover

XXXII, 838 Seiten

2020 | 1. Auflage
Wiley-VCH (Verlag)
978-3-527-34681-3 (ISBN)

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A must-have resource for all the researchers working in the organofluorine and related fieldsThis timely two-volume set uniquely focuses on emerging fluorinated motifs beyond R-CF3 and R-F, like R-CF2H, R-OCF3, R-SCF3 and R-SF5. It also offers descriptions of the properties, synthesis, and applications of these emerging fluorinated motifs in order to help readers design new chemical entities, while providing new interest for researchers in organofluorine chemistry and new tools for those in other areas.Emerging Fluorinated Motifs: Synthesis, Properties and Applications begins with a description of carbon-linked fluorine-containing groups that include monofluoromethyl and difluoromethyl groups. It then details combinations of heteroatoms, Oxygen, Sulfur, Selenium, Nitrogen, and Phosphorus with fluorine-containing groups, outlining subsections of the most popular current motifs. Fluoroalkyl ethers, thioethers, and the recent blossoming of the SF5 unit is covered. Other chapters look at: selenium-linked fluorine-containing motifs; construction of N-CF2H, N-CF3, N-CH2CF3 motifs; and the synthesis and applications of P-Rf-containing molecules. -Focuses on the synthesis, properties, and applications of emerging fluorinated motifs-Covers carbon-linked fluorine-containing motifs, oxygen-linked fluorine-containing motifs, sulfur-linked fluorine-containing motifs, and more-Appeals to academic and industrial researchers working in organic chemistry, medicinal chemistry, food chemistry, and materials science-Edited by world-renowned experts in organofluorine chemistryEmerging Fluorinated Motifs is intended for academic research institutes, university libraries, researchers, graduate students, postdoctors, and researchers in the chemical industry.

Dominique Cahard, PhD, is Director of Research at the French National Center for Scientific Research, CNRS. His current research interests concern innovative methodologies for asymmetric synthesis of fluorinated molecules and the synthesis of fluorinated biomolecules. Jun-An Ma, PhD, is a Full Professor of organic chemistry and the Vice Dean of the School of Science at Tianjin University. His current research efforts are focused on organofluorine chemistry and catalytic asymmetric synthesis.

Volume I

Part I: Carbon-Linked Fluorine-Containing Motifs
Chapter 1: Difluoromethylation and Difluoroalkylation of (Hetero)Arenes. Access to Ar(Het)-CF2H and Ar(Het)-CF2R
Chapter 2: Difluoromethylation and Difluoroalkylation of Aliphatic Unsaturated C=C, CC,-NC Bonds
Chapter 3: Difluoromethylation and Difluoroalkylation at Csp3 Centres, C=O , C=C, and C=N Bonds
Chapter 4: Monofluoromethylation Reactions of Aliphatic Substrates and (Hetero)Arenes
Chapter 5: Synthesis of gem-Difluorocyclopropanes

Part II: Oxygen-Linked Fluorine-Containing Motifs
Chapter 6: Indirect Construction of the OCF3 Motif
Chapter 7: Reagents for Direct Trifluoromethoxylation
Chapter 8: Direct Trifluoromethoxylation of Aromatics and Heteroaromatics
Chapter 9: Direct Trifluoromethoxylation of Aliphatic Compounds
Chapter 10: Extension to the Construction of ORf Motifs (OCF2H, OCFH2, OCH2CF3, OCFHCH3)

Volume II
Part III: Sulfur-Linked Fluorine-Containing Motifs
Chapter 11: Indirect Trifluoromethylthiolation Methods
Chapter 12: Reagents for Direct Trifluoromethylthiolation
Chapter 13: Trifluoromethylthiolation of Aromatics and Heteroaromatic Compounds
Chapter 14: Synthesis of Trifluoromethylthiolated Alkenes and Alkynes
Chapter 15: Direct Trifluoromethylthiolation toward C(sp3)-SCF3 Compounds
Chapter 16: Extension to the SCF2H, SCH2F, and SCF2R motifs (R = PO(OEt)2, CO2R, Rf)
Chapter 17: Synthesis and Applications of Fluorinated Sulfoxides (RSORf) and Sulfones (RSO2Rf)
Chapter 18: Pentafluorosulfanylation of Aromatics and Heteroaromatics
Chapter19: Pentafluorosulfanylation of Aliphatic Substrates
Chapter 20: Extension to SF4CF3 and SF4FG Groups
Chapter 21: Properties & applications of sulfur(VI) fluorides
Chapter 22: Construction S-Rf Sulfilimines and S-Rf Sulfoximines

Part IV: Selenium-Linked Fluorine-Containing Motifs
Chapter 23: When Fluorine Meets Selenium

Part V: Nitrogen-Linked Fluorine-Containing Motifs
Chapter 24: Construction of N-CF2H, N-CF3, N-CH2CF3 Motifs

Part VI: Phosphorus-Linked Fluorine-Containing Motifs
Chapter 25: Synthesis and Applications of P-Rf-Containing Molecules

Erscheinungsdatum	20.05.2020
Verlagsort	Weinheim
Sprache	englisch
Maße	170 x 244 mm
Gewicht	1970 g
Themenwelt	Naturwissenschaften ► Biologie
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Biochemie • biochemistry • Biowissenschaften • Chemie • Chemistry • Life Sciences • Organic Chemistry • Organische Chemie • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie
ISBN-10	3-527-34681-3 / 3527346813
ISBN-13	978-3-527-34681-3 / 9783527346813
Zustand	Neuware