Target Organ Toxicology in Caenorhabditis elegans

Dayong Wang (Autor)

Buch | Hardcover

337 Seiten

2019 | 1st ed. 2019
Springer Verlag, Singapore
978-981-13-6009-1 (ISBN)

Artikel merken

This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes’ avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed.

As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.

Dr. Dayong Wang is a professor at the Medical School, Southeast University, China. He obtained his Ph.D. from Peking University in 2001 and completed his post-doctoral training at the University of Toronto from 2002 to 2004. His research focuses on toxicology and pathology using Caenorhabditis elegans as a model animal, fields in which he has published more than 160 research articles.

Protective Responses of Different Organs to Environmental Toxicants or Stresses.- Avoidance Behaviour of Nematodes to Environmental Toxicants or Stresses.- Intestinal Barrier for Nematodes against Toxicity of Environmental Toxicants or Stresses.- Epidermal Barrier for Nematodes against Toxicity of Environmental Toxicants or Stresses.- Toxicity Induction in Intestine and Epidermis in Nematodes Exposed to Environmental Toxicants or Stresses.- Toxicity Induction in Neurons and Muscle in Nematodes Exposed to Environmental Toxicants or Stresses.- Reproductive Toxicity Induction in Nematodes Exposed to Environmental Toxicants or Stresses.- Intestinal Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.- Epidermal Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.- Neuronal Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.- Germline Signalling Pathways Required for the Regulation of Toxicity of Environmental Toxicants or Stresses.

Erscheinungsdatum	01.03.2019
Zusatzinfo	175 Illustrations, color; 57 Illustrations, black and white; XIII, 337 p. 232 illus., 175 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Caenorhabditis elegans • Environmental Stresses • Environmental toxicants • signalling pathways • Target organ toxicology
ISBN-10	981-13-6009-X / 981136009X
ISBN-13	978-981-13-6009-1 / 9789811360091
Zustand	Neuware