Antimicrobial Peptides

Basics for Clinical Application

Buch | Hardcover

304 Seiten

2019 | 1st ed. 2019
Springer Verlag, Singapore
978-981-13-3587-7 (ISBN)

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This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

Katsumi Matsuzaki is a Professor at the Graduate School of Pharmaceutical Sciences, Kyoto University, where he also completed his PhD in Biophysical Chemistry. Dr. Matsuzaki has authored more than 100 publications, which have been cited more than 10000 times. In addition to serving as an editor for Biochimica et Biophysica Acta-Biomembranes, Journal of Peptide Science, and European Biophysics Journal, he is a member of the Biophysical Society (USA), The Pharmaceutical Society Japan, The Japanese Peptide Society, and The Biophysical Society of Japan. He was awarded The Japanese Peptide Society Award for Young Scientists, The Pharmaceutical Society Japan Award for Young Scientists, and the Erwin von Bälz Prize. His primary research interest is in membrane biophysics, including peptide–membrane interactions and in-cell biophysics.

Part 1. Introduction.- Chapter 1. Antimicrobial peptides of multicellular organisms: My perspective.- Part 2. Mechanisms of Antimicrobial Action.- Chapter 2. Membrane permeabilization mechanisms.- Chapter 3. Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes --- single GUV studies ----.- Chapter 4. The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations.- Chapter 5. Anionic lipid clustering model.- Chapter 6. Intracellular antimicrobial peptides targeting the protein synthesis machinery.- Part 3. Other activities of AMPs.- Chapter 7. Antimicrobial and cell-penetrating peptides: How to understand two distinct functions despite similar physicochemical properties.- Chapter 8. Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs).- Chapter 9. Anti-cancer activities of natural and synthetic peptides.- Chapter 10. Antimicrobial host defence peptides: Immunomodulatory functions and translational prospects.- Part 4. Towards Clinical Applications.- Chapter 11. Activity and selectivity of antimicrobial peptides: A complex interplay of multiple equilibria.- Chapter 12. Design of antimicrobial peptides: Progress made with human cathelicidin LL-37.- Chapter 13. Application of synthetic molecular evolution to the discovery of antimicrobial peptides.- Chapter 14. AMPs as anti-biofilm agents for human therapy and prophylaxis.- Chapter 15. Clinical application of AMPs.

Erscheinungsdatum	25.04.2019
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1117
Zusatzinfo	55 Illustrations, color; 18 Illustrations, black and white; VIII, 304 p. 73 illus., 55 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
Schlagworte	Anticancer agent • Antisepsis agent • clinical application • Mechanism of Action • Peptide translocation
ISBN-10	981-13-3587-7 / 9811335877
ISBN-13	978-981-13-3587-7 / 9789811335877
Zustand	Neuware