Dual-Mode Electro-photonic Silicon Biosensors
Seiten
2018
|
1. Softcover reprint of the original 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-86872-1 (ISBN)
Springer International Publishing (Verlag)
978-3-319-86872-1 (ISBN)
This highly interdisciplinary thesis reports on two innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach's ability to study molecular conformation and conformational changes in real time is demonstrated.
The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed bysimultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.
The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed bysimultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.
Introduction.- Fundamentals of Label-Free Biosensing.- Fabrication and Experimental Techniques.- The Electro-photonic Silicon Biosensor.- Study and Application of Electrografted Layers of Diazonium Ions.- Tailoring Light-matter Interaction for Quantification of Biological and Molecular Layers.- Conclusions and Outlook.
| Erscheint lt. Verlag | 4.8.2018 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XV, 149 p. 105 illus., 89 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 2642 g |
| Themenwelt | Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik |
| Schlagworte | Electro-photonic Biosensor • Multiplexed DNA Detection • Photonic Biosensing • Quantifying biomolecular layers • Ring Resonators Biosensors • Silicon Biosensing |
| ISBN-10 | 3-319-86872-1 / 3319868721 |
| ISBN-13 | 978-3-319-86872-1 / 9783319868721 |
| Zustand | Neuware |
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