Non-Neuronal Mechanisms of Brain Damage and Repair After Stroke

Jun Chen, John H. Zhang, Xiaoming Hu (Herausgeber)

Buch | Softcover

XIII, 408 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-81260-1 (ISBN)

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This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials.

Part 1. Microvascular integrity in stroke.- 1. Structural alterations to the endothelial tight junction complex during stroke.- 2. Role of pericytes in neurovascular unite and stroke.- 3. Glial support of blood-brain barrier integrity: Molecular targets for novel therapeutic strategies in stroke.- 4. Barrier mechanism in neonatal stroke.- 5. Angiogenesis: a realistic therapy for ischemic stroke.- Part 2. Glial cells in stroke.- 6. Astrocytes as a target for ischemic stroke.- 7. Microglia: a double-sided sword in stroke.- 8. Crosstalk between cerebral endothelium and oligodendrocyte after stroke.- Part 3. Peripheral immune cells in stroke.- 9. The peripheral immune response to stroke.- 10. The Role of spleen-derived immune cells in ischemic brain injury.- 11. Regulatory T cells in ischemic brain injury.- 12. B cells in stroke and preconditioning-induced protection against stroke.- 13. Mast cell as an early responder in ischemic brain injury.- 14. Roles of neutrophils in stroke.- 15. Thefunction of cytokines in ischemic stroke.- Part 4. White matter injury and repair in stroke.- 16. Ischemic injury to white matter: an age-dependent process.- 17. Neurovascular repair after stroke.- 18. The role of non-neuronal Nrf2 pathway in ischemic stroke: damage control and potential tissue repair.- 19. Stem cell therapy for ischemic stroke.

Erscheinungsdatum	05.03.2022
Reihe/Serie	Springer Series in Translational Stroke Research
Zusatzinfo	XIII, 408 p. 49 illus., 44 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	646 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	blood brain barrier • Brain Repair • Neuroinflammation • therapies • white matter
ISBN-10	3-319-81260-2 / 3319812602
ISBN-13	978-3-319-81260-1 / 9783319812601
Zustand	Neuware