Molecular Dynamics Analyses of Prion Protein Structures (eBook)

The Resistance to Prion Diseases Down Under

Jiapu Zhang (Autor)

eBook Download: PDF

2018 | 1st ed. 2018
XXIX, 375 Seiten
Springer Singapore (Verlag)
978-981-10-8815-5 (ISBN)

Infos

Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called 'protein structural conformational' diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrP^C) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.

Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the β2-α2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.

Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross-β structure PrP peptides are well studied.   

This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

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Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "e;protein structural conformational"e; diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too; firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book.Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the 2-a2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Straussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book.Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross- structure PrP peptides are well studied.   This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

Inhalt

PrefaceBasic Knowledge Part I Prion Resistance Species2 Rabbits -Wild-type and Mutants 3 Dogs -Wild-type and D159NMutant 4 Horses, Buffaloes, and Pigs 5 Chicken, Turtles, and Frogs 6 Other Species Part II b 2-a2 Loop7 Wild-type Mouse 37 oC and 19.85 oC Structures 8 Mouse Mutants 9 Other Species with an Ordered b 2-a2 Part III Human Mutants10 Human Mutants11 Human PrPC Monomer, Dimer and Its M129V Mutant 12 Human PeptidesPart IV PrP Binding/Docking13 PrP Bounded to Antibodies, Nanobody, RNA aptamer, etc. 14 Potential Antiprion Drugs Part V Prion Peptides with Cross-b Structures15 Mathematical Formulas for All PrP Peptides’ cross-b structures 16 Hydrogen Bonds Between Two Optimized Fundamental Chains ofEach Model References 

Produkt-Details

• Erscheint lt. Verlag: 20.7.2018
• Reihe/Serie: Focus on Structural Biology
• Reihe/Serie: Focus on Structural Biology
• Zusatzinfo: XXIX, 375 p. 596 illus., 278 illus. in color.
• Verlagsort: Singapore
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Schlagworte: Molecular Dynamics Simulation • molecular structure • Prion Infection • Prion Protein Structure • Proteomics • structural dynamics
• ISBN-10: 981-10-8815-2 / 9811088152
• ISBN-13: 978-981-10-8815-5 / 9789811088155