Glucose-sensing Receptor in Pancreatic Beta-cells (eBook)

Itaru Kojima (Herausgeber)

eBook Download: PDF

2018 | 1st ed. 2018
V, 71 Seiten
Springer Singapore (Verlag)
978-981-13-0002-8 (ISBN)

Infos

Since the 1970s, there has been much discussion about the 'glucoreceptor' and 'substrate site' and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the 'glucoreceptor theory.'

This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.

The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: 'glucoreceptor theory'.

Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. 

Itaru Kojima, M.D. Professor Emeritus                                               

Institute for Molecular & Cellular Regulation, Gunma University 

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Since the 1970s, there has been much discussion about the "e;glucoreceptor"e; and "e;substrate site"e; and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the "e;glucoreceptor theory."e;This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: "e;glucoreceptor theory"e;. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. 

Inhalt

.-1  HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR.-2Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells.-3KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR.-4Signaling System Activated by the Glucose-sensing Receptor.-5The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells

Produkt-Details

• Erscheint lt. Verlag: 31.5.2018
• Zusatzinfo: V, 71 p. 15 illus., 7 illus. in color.
• Verlagsort: Singapore
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie
• Schlagworte: Diabetes • Glucoreceptor • Insulin Secretion • Metabolism • Sweet Taste Receptor
• ISBN-10: 981-13-0002-X / 981130002X
• ISBN-13: 978-981-13-0002-8 / 9789811300028