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Carbohydrate-Based Interactions at the Molecular and the Cellular Level (eBook)

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2018 | 1st ed. 2018
XXIX, 198 Seiten
Springer International Publishing (Verlag)
978-3-319-77706-1 (ISBN)

Lese- und Medienproben

Carbohydrate-Based Interactions at the Molecular and the Cellular Level - Kieran L. Hudson
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This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH-pi interactions associated with the properties of the interacting partners. 

Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.



Dr Kieran Hudson received a Master of Chemistry degree from the University of Oxford, UK in 2011. During his research there he developed an interest in the intersection of chemistry and biology, particularly in how small structural differences in biomolecules have substantial effects in nature. He developed this interest during his postgraduate research at the University of Bristol, UK, from where he obtained a PhD with a Faculty of Science Commendation in 2016. Dr Hudson is currently continuing his research as a postdoctoral fellow at the University of British Columbia, Canada.

Dr Kieran Hudson received a Master of Chemistry degree from the University of Oxford, UK in 2011. During his research there he developed an interest in the intersection of chemistry and biology, particularly in how small structural differences in biomolecules have substantial effects in nature. He developed this interest during his postgraduate research at the University of Bristol, UK, from where he obtained a PhD with a Faculty of Science Commendation in 2016. Dr Hudson is currently continuing his research as a postdoctoral fellow at the University of British Columbia, Canada.

Introduction.- Protein-Carbohydrate Interactions in Protein X-ray Crystal Structures.- The Nature of Protein-Carbohydrate Interactions.- The Modifiable Scaffold for Tissue Engineering.- Carbohydrate Modifiers for Tissue Engineering Scaffolds.- Conclusions and Future Directions.- Experimental Details and Supplementary Data.

Erscheint lt. Verlag 28.5.2018
Reihe/Serie Springer Theses
Springer Theses
Zusatzinfo XXIX, 198 p. 98 illus., 49 illus. in color.
Verlagsort Cham
Sprache englisch
Themenwelt Naturwissenschaften Biologie
Naturwissenschaften Chemie Organische Chemie
Schlagworte Aromatic Interactions • carbohydrate chemistry • Cellular Development • CH-pi Interactions • Functionalised Materials • Ligand binding • Peptide-based Materials • Protein-Carbohydrate Interactions • Protein-Ligand Interactions • Smart biomaterials
ISBN-10 3-319-77706-8 / 3319777068
ISBN-13 978-3-319-77706-1 / 9783319777061
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