Chromosome Translocation

Yu Zhang (Herausgeber)

Buch | Hardcover

168 Seiten

2018 | 1st ed. 2018
Springer Verlag, Singapore
978-981-13-0592-4 (ISBN)

Artikel merken

This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases.

The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation.

It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.

Dr. Yu Zhang is Assistant Investigator at National Institute of Biological Sciences, Beijing, China.

Chapter 1: Historical and clinical overview of chromosome translocations.- Chapter 2: Next generation sequencing to identify chromosome translocation.- Chapter 3: The experimental models to study chromosome translocations.- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome.- Chapter 5: Live cell imaging to study chromosome translocation.- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo.- Chapter 7: Generation of DNA double strand breaks (DSBs).- Chapter 8: The role of DSB response pathway in regulating chromosome translocation.- Chapter 9: DSB repair and ligation of chromosome translocation.- Chapter 10: 3D genome organization defines the chromosome translocation pattern.- Chapter 11: Mechanisms of chromosome deletion.- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.

Erscheinungsdatum	21.09.2018
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1044
Zusatzinfo	27 Illustrations, color; 2 Illustrations, black and white; V, 168 p. 29 illus., 27 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	981-13-0592-7 / 9811305927
ISBN-13	978-981-13-0592-4 / 9789811305924
Zustand	Neuware