New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules (eBook)
XXI, 157 Seiten
Springer International Publishing (Verlag)
978-3-319-74914-3 (ISBN)
This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas.
Organocatalysis is a relatively modern and 'hot' topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also pose a number of challenges, the most notable of which are their reduced reactivity and the reduced stereocontrol at these positions. On the other hand, atropisomeric systems are even more important because of the huge potential they have as drugs, ligands and catalysts. Chemists have only recently 'recognized' the importance of these two areas and are focusing their efforts on studying them and the challenges they pose.
This thesis offers an extensive introduction on the general aspects of chirality and organocatalysis and an equally extensive experimental section that allow nonexperts to understand the discussion section and reproduce the experiments.
Nicola Di Iorio was born in 1989. During his studies at the University of Bologna, Italy he spent a year abroad at UCLA (University of California, Los Angeles, USA) before graduating (cum laude) in Industrial Chemistry in October 2013. Immediately afterwards, he started his doctoral studies on asymmetric organocatalysis, focusing particularly on unconventional axial chirality. In February 2017 he received the 'Spada Award' for Ph.D. students who have distinguished themselves in productivity, innovation and scientific independence. Two months later, he completed his Ph.D. and is currently working as a postdoc at the Department of Industrial Chemistry at the University of Bologna.
Nicola Di Iorio was born in 1989. During his studies at the University of Bologna, Italy he spent a year abroad at UCLA (University of California, Los Angeles, USA) before graduating (cum laude) in Industrial Chemistry in October 2013. Immediately afterwards, he started his doctoral studies on asymmetric organocatalysis, focusing particularly on unconventional axial chirality. In February 2017 he received the “Spada Award” for Ph.D. students who have distinguished themselves in productivity, innovation and scientific independence. Two months later, he completed his Ph.D. and is currently working as a postdoc at the Department of Industrial Chemistry at the University of Bologna.
Introduction.- The Vinylogous Reactivity of Oxindoles Bearing Non-symmetric 3-Alkylidene Groups.- Targeting the Remote Control of Axial Chirality in N-(2-tert-Butylphenyl)Succinimides via a Desymmetrization Strategy.- Direct Catalytic Synthesis of C(sp2)-C(sp3) Atropisomers with Simultaneous Control of Central and Axial Chirality.
| Erscheint lt. Verlag | 11.4.2018 |
|---|---|
| Reihe/Serie | Springer Theses | Springer Theses |
| Zusatzinfo | XXI, 157 p. 33 illus., 28 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Themenwelt | Naturwissenschaften ► Chemie ► Physikalische Chemie |
| Technik | |
| Schlagworte | Aminocatalysis • Atropisomers • Axial Chirality • Desymmetrization • Enamine Catalysis • Friedel-Crafts reaction • Iminium Ion Catalysis • Organocatalysis • Oxindoles • Vinylogous Reactivity |
| ISBN-10 | 3-319-74914-5 / 3319749145 |
| ISBN-13 | 978-3-319-74914-3 / 9783319749143 |
| Haben Sie eine Frage zum Produkt? |
PDF (Wasserzeichen)Größe: 11,4 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich
