Metallo-Drugs: Development and Action of Anticancer Agents (eBook)

Development and Action of Anticancer Agents

Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K.O. Sigel (Herausgeber)

eBook Download: PDF

2018 | 1. Auflage
588 Seiten
Walter de Gruyter GmbH & Co.KG (Verlag)
978-3-11-047073-4 (ISBN)

Infos

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Helmut and Astrid Sigel, University of Basel, Switzerland; Roland K. O. Sigel and Eva Freisinger, University of Zürich, Switzerland.

Produkt-Details

• Erscheint lt. Verlag: 5.2.2018
• Co-Autor: Enzo Alessio, Sharnel A. S. Clatworthy, Debbie Crans, Delphine Denoyer, Nicholas P. Farrell, Anil K. Gorle, Allison Haase, Michael John Hannon, Christian G. Hartinger, Hannah U. Holtkamp, Jana Kasparkova, Wee Han Ang, Stephen J. Lippard, Vijay Menon, Luigi Messori, Maya Miller, Olivia Ogle, Ingo Ott, Erica J. Peterson, Imogen Riddell, Peter J. Sadler, Ulrich Schatzschneider, Maria V. Babak, Matthew P. Sullivan, Raymond Wai-Yin Sun, Kathryn M. Taylor, Frank Thevenod, Edit Tshuva, V. Venkatesh, Ramon Vilar, Lining Yan, Xiaogai Yang, Silvia Ziliotto, Susan Berners-Price, Victor Brabec, Lucia Cardo, Angela Casini, Michael Cater, Christopher Chitambar
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Chemie ► Anorganische Chemie
• ISBN-10: 3-11-047073-X / 311047073X
• ISBN-13: 978-3-11-047073-4 / 9783110470734