Total Synthesis of Natural Products with Antimicrobial Activity

Andrew Giltrap (Autor)

Buch | Hardcover

268 Seiten

2018 | 1st ed. 2018
Springer Verlag, Singapore
978-981-10-8805-6 (ISBN)

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This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

Andrew M. Giltrap was raised in Sydney, Australia and carried out his Bachelor of Science majoring in chemistry at the University of Sydney. During this time, Andrew undertook his final year undergraduate research project under the supervision of Professor Richard J. Payne, receiving the University Medal for undergraduate excellence. Andrew continued in the laboratory of Professor Payne, commencing his PhD studies in 2013 funded by an Australian Postgraduate Award, the Sydney University Vice-Chancellor’s Research Scholarship and the John A. Lamberton Scholarship. During his PhD, Andrew’s research focused on the total synthesis of antimicrobial peptide natural products, notably completing the first total syntheses of teixobactin and skyllamycins A-C. He is currently a postdoctoral research associate at the University of Sydney.

Introduction.- Total Synthesis of Teixobactin.- Synthesis of Deshydroxy Skyllamycins A-C.- Total Synthesis of Skyllamycins A-C.- Experimental.

Erscheinungsdatum	29.07.2018
Reihe/Serie	Springer Theses
Zusatzinfo	59 Illustrations, color; 85 Illustrations, black and white; XXIV, 268 p. 144 illus., 59 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Physikalische Chemie
Schlagworte	Antimicrobial Resistance • Deshydroxy Skyllamycin • Gram-positive Bacterial Pathogens • Non-Ribosomal Peptides (NRPs) • -OH-Gly • Proteinogenic Amino Acids • Pseudomonas aeruginosa Biofilms • Skyllamycins A-C • Teixobactin • total synthesis • α-OH-Gly
ISBN-10	981-10-8805-5 / 9811088055
ISBN-13	978-981-10-8805-6 / 9789811088056
Zustand	Neuware