Targeting Trafficking in Drug Development

Alfredo Ulloa-Aguirre, Ya-Xiong Tao (Herausgeber)

Buch | Hardcover

VIII, 425 Seiten

2018
Springer International Publishing (Verlag)
978-3-319-74163-5 (ISBN)

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Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

1. Intracellular trafficking of gonadotropin receptors in health and disease.- 2. Investigating internalization and intracellular trafficking of GPCRs.- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors.- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases.- 5. Pharmacoperones for misfolded gonadotropin receptors.- 6. Pharmacological chaperones: Beyond conformational disorders.- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer.- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches.- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking.- 10. SLC6 transporter folding diseases and pharmacochaperoning.- 11. The molecular physiopathogenesis of islet amyloidosis.- 12. Folding defects leading to primary hyperoxaluria.- 13. Potentialpharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.

Erscheinungsdatum	06.03.2018
Reihe/Serie	Handbook of Experimental Pharmacology
Zusatzinfo	VIII, 425 p. 57 illus., 55 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	811 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Golgi • Misfolding • mutant rescue • pharmacoperone • Therapeutic Intervention • Trafficking
ISBN-10	3-319-74163-2 / 3319741632
ISBN-13	978-3-319-74163-5 / 9783319741635
Zustand	Neuware