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Organometallic Chemistry in Industry

A Practical Approach

Thomas Colacot, Carin Johansson Seechurn (Herausgeber)

Buch | Hardcover

XX, 316 Seiten

2020 | 1. Auflage
Wiley-VCH (Verlag)
978-3-527-34517-5 (ISBN)

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Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studiesThis comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more.-Includes rare industrial case studies difficult to find in current literature-Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation-Features a foreword by Nobel Laureate R. H. Grubbs-A perfect resource for every R&D researcher in industry-Useful for PhD students and postdocs: excellent preparation for a job interviewOrganometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Thomas J. Colacot is R&D Fellow, and Director of Global Technology Innovation (Lab and Specialty Chemicals) at Millipore Sigma, USA. His expertise is in the areas of new product and technology development, process R&D, scale-up, tech transfers of organic, organometallic and fine chemicals relevant for pharmaceutical, electronic, and biological applications with very strong interactions/partnership with customers. He is one of the outstanding scientists featured by Merck: https://www.merckgroup.com/en/research/science-space/scientists/thomas-colacot.html Carin Johansson Seechurn is researcher in the Catalysis and Chiral Technologies division of Johnson Matthey in Royston, UK, where she is working on the development and scale-up of novel homogeneous metal catalysts.

INDUSTRIAL MILESTONES IN ORGANOMETALLIC CHEMISTRY
DESIGN, DEVELOPMENT AND EXECUTION OF A CONTINUOUS FLOW ENABLED API MANUFACTURING ROUTE
CONTINUOUS MANUFACTURING AS AN ENABLING TECHNOLOGY FOR LOW TEMPERATURE ORGANOMETALLIC CHEMISTRY
DEVELOPMENT OF A NICKEL-CATALYZED ENANTIOSELECTIVE MIZOROKI-HECK COUPLING
DEVELOPMENT OF IRON-CATALYZED KUMADA CROSS-COUPLING FOR THE LARGE SCALE PRODUCTION OF ALISKIREN INTERMEDIATE
DEVELOPMENT AND SCALE-UP OF A PALLADIUM-CATALYZED INTRAMOLECULAR DIRECT ARYLATION IN THE COMMERCIAL SYNTHESIS OF BECLABUVIR
RUTHENIUM CATALYZED C-H ACTIVATED C-C/N/O BOND FORMATION REACTIONS FOR THE PRACTICAL SYNTHESIS OF HETEROCYCLES AND PHARMACEUTICAL AGENTS
CROSS-COUPLINGS IN WATER - A BETTER WAY TO ASSEMBLE NEW BONDS
ASPECTS OF HOMOGENEOUS HYDROGENATION FROM INDUSTRIAL RESEARCH
LATEST INDUSTRIAL USES OF OLEFIN METATHESIS
DEHYDRATIVE DECARBONYLATION

Erscheinungsdatum	18.03.2020
Vorwort	Robert H. Grubbs
Verlagsort	Weinheim
Sprache	englisch
Maße	170 x 244 mm
Gewicht	806 g
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik
Schlagworte	Catalysis & Chemical Reaction Engineering • chemical engineering • Chemie • Chemische Verfahrenstechnik • Chemistry • Industrial Chemistry • Katalyse • Katalyse u. Chemische Reaktionstechnik • Metallorganische Verbindungen • Organometallchemie • Organometallic Chemistry • Technische u. Industrielle Chemie
ISBN-10	3-527-34517-5 / 3527345175
ISBN-13	978-3-527-34517-5 / 9783527345175
Zustand	Neuware