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DJ-1/PARK7 Protein -

DJ-1/PARK7 Protein (eBook)

Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases
eBook Download: PDF
2017 | 1st ed. 2017
VIII, 222 Seiten
Springer Singapore (Verlag)
978-981-10-6583-5 (ISBN)
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This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. 



Hiroyoshi Ariga
Faculty of Pharmaceutical Sciences, Hokkaido University
Sapporo, Japan
Sanae M.M. Iguchi-Ariga
Faculty of Agriculture, Hokkaido University
Sapporo,Japan

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson's disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader willdiscover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases.

Hiroyoshi ArigaFaculty of Pharmaceutical Sciences, Hokkaido UniversitySapporo, JapanSanae M.M. Iguchi‐ArigaFaculty of Agriculture, Hokkaido UniversitySapporo,Japan

Erscheint lt. Verlag 16.11.2017
Reihe/Serie Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology
Zusatzinfo VIII, 222 p. 78 illus., 46 illus. in color.
Verlagsort Singapore
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Biologie Zoologie
Schlagworte Biomarker • Cancer • DJ-1 • male infertility • mitochondria • Oxidative stress • Parkinson’s disease • signal transduction • Therapeutic drug • type 2 diabetes
ISBN-10 981-10-6583-7 / 9811065837
ISBN-13 978-981-10-6583-5 / 9789811065835
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