New Applications of NMR in Drug Discovery and Development (eBook)

Leoncio Garrido, Nicolau Beckmann (Herausgeber)

eBook Download: PDF

2013
304 Seiten
Royal Society of Chemistry (Verlag)
978-1-84973-766-1 (ISBN)

Infos

This book presents a review of new developments in NMR for applications in medicinal chemistry and drug discovery. The contents will focus on consolidated and emerging techniques and methods that are at present not widely applied, however it is considered that they could contribute to the advancement of drug discovery and drug development.

Inhalt

Introduction; Part I. Small Molecules, Proteins, Cellular Systems: New Applications of High Resolution NMR in Drug Discovery and Development; Solid-state NMR in Drug Discovery and Development; High Resolution NMR-Based Metabolic Profiling in Drug Discovery and Development; In-Cell NMR Spectroscopy to Study Protein-Drug Interactions; Part II. The Whole Organism in Vivo: Increased Sensitivity Using Cryogenic Radiofrequency Coils: Application to In Vivo Phenotyping of Mice; Recent Developments of Contrast Agents, CEST and Low Fields; Pharmacological fMRI in Drug Discovery and Development; In Vivo Proton MR Spectroscopy: Animal and Human Applications at High Fields; Hyperpolarization: Concepts, Techniques and Applications; Combined PET/MRI for Improving Quantitative Imaging; Magnetic Resonance based Cell Imaging using Contrast Media and Reporter Genes; Part III. Translational drug discovery: From Biological Models to the Clinics:Translational Magnetic Resonance Imaging and Spectroscopy: Opportunities and Challenges; In vivo MRI/S for the Safety Evaluation of Pharmaceuticals; Applications of MRI and MRS in Cartilage Therapeutics and Tissue Engineering; Applications of Magnetic Resonance Spectroscopy to Psychiatric Disorders; Structural Magnetic Resonance Imaging Biomarkers in Neurodegenerative Disease; Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development; Cardiovascular Magnetic Resonance; Magnetic Resonance Imaging Techniques in Cancer; Subject Index;

Produkt-Details

• Erscheint lt. Verlag: 18.7.2013
• Reihe/Serie: ISSN
• Reihe/Serie: ISSN
• Verlagsort: Cambridge
• Sprache: englisch
• Themenwelt: Sachbuch/Ratgeber ► Freizeit / Hobby ► Sammeln / Sammlerkataloge
• Themenwelt: Naturwissenschaften ► Chemie ► Analytische Chemie
• Schlagworte: Applications • Development • Discovery • Drug • New • NMR
• ISBN-10: 1-84973-766-5 / 1849737665
• ISBN-13: 978-1-84973-766-1 / 9781849737661