Circadian Rhythms and Their Impact on Aging (eBook)

S. Michal Jazwinski, Victoria P Belancio, Steven M Hill (Herausgeber)

eBook Download: PDF

2017 | 1st ed. 2017
XIII, 361 Seiten
Springer International Publishing (Verlag)
978-3-319-64543-8 (ISBN)

Infos

Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

S. Michal Jazwinski, Ph.D. is the John W. Deming, M.D. Regents Chair in Aging, Professor of Medicine, and Director of the Tulane Center for Aging at Tulane University.  His research on various aspects of aging has been funded by the National Institute on Aging (NIH) and private foundations, and it spans over thirty years.  It includes genetic studies in model organisms and multidisciplinary studies in humans.

Victoria P. Belancio, Ph.D. is an Associate Professor of Structural and Cellular Biology at Tulane University. Her research on retrotransposon-associated genomic instability has been funded by the National Institute on Aging (NIH) and private foundations. It includes projects investigating how circadian disruption impacts DNA damage induced by retroelements and whether this damage influences mammalian aging.

Steven M. Hill, Ph.D. is the Edmond and Lily Safra Chair for Breast Cancer Research, Professor of Structural & Cellular Biology, and Director of the Tulane Center for Circadian Biology at Tulane University.  His research on various aspects of circadian biology and breast cancer has been funded by the National Cancer Institute (NIH), the Army Department of Defense Breast Cancer Program, and private foundations, and spans over 25 years.   His recent research efforts have focused on the impact of circadian/melatonin disruption by light at night on human breast cancer progression, metastasis, and drug resistance.

Inhalt

1-      The yeast metabolic cycle, cell cycle, and lifespan Benjamin Tu 2-      The Neurospora biological clock and aging Jonathan Arnold 3-      The circadian clock and aging of Drosophila Jadwiga Giebultowicz 4-      Mammalian models of circadian biology with emphasis on aging Marina Antoch 5-      Organization and functional dynamics of circadian clocks in mammalian model systems in relation to aging Joseph Takahashi 6-      Age-related changes in circadian and nuclear receptor cross talk David Mangelsdorf 7-      Circadian integration of whole animal mammalian metabolism and energetics Joseph Bass 8-      Circadian rhythms of metabolism and chromatin remodeling Paolo Sassone-Corsi 9-      The circadian clock and mTOR Roman Kondratov 10-  Cell senescence, DDR, SASP and genomic instability Judy Campisi 11-  Circadian control of DNA repair Aziz Sancar 12-  Epidemiology of circadian disruption and human health Richard Stevens 13-  Impact of melatonin – reciprocal relationship with aging Russ Reiter 14-  Aging and circadian misalignment on inflammation and immune response pathways Regina Markus 15-     Impact of the circadian system and its misalignment on metabolic and cardiovascular dynamics Frank Scheer 16-     Detoxification and the circadian system Anton Jetten 17-     Circadian system and bone metabolism Paula Witt-Enderby 18-     Circadian sleep-wake regulation during aging Steven Lockley 19-     Modeling the eukaryotic cell cycle John Tyson 20-     Circadian system and responses to chronotherapy William HrusheskyI

Produkt-Details

• Erscheint lt. Verlag: 24.10.2017
• Reihe/Serie: Healthy Ageing and Longevity
• Reihe/Serie: Healthy Ageing and Longevity
• Zusatzinfo: XIII, 361 p. 41 illus., 15 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Studium
• Themenwelt: Naturwissenschaften ► Biologie
• Schlagworte: circadian rhythms • Diseases of aging • Genome Stability • Healthy Aging • Metabolism
• ISBN-10: 3-319-64543-9 / 3319645439
• ISBN-13: 978-3-319-64543-8 / 9783319645438