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Modelling Proteasome Dynamics in a Bayesian Framework

Sabine Stübler (Autor)

Buch | Softcover

XV, 96 Seiten

2017 | 1st ed. 2017
Springer Fachmedien Wiesbaden GmbH (Verlag)
978-3-658-20166-1 (ISBN)

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Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor's transport parameters for strong or isoform-specific inhibition.

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Structure and Function of the Proteasome.- Approaches to Model Proteasome Dynamics.- Comparison of the Dynamics of Proteasome Subtypes.- Inhibitor Influence on the Catalytic Subunits.- Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model .

Erscheinungsdatum	05.01.2018
Reihe/Serie	BestMasters
Zusatzinfo	XV, 96 p. 30 illus., 10 illus. in color.
Verlagsort	Wiesbaden
Sprache	englisch
Maße	148 x 210 mm
Gewicht	156 g
Themenwelt	Informatik ► Weitere Themen ► Bioinformatik
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Approximate Bayesian Computation • Enzyme kinetics • Immunoproteasome • Modelling Proteasome Dynamics in a Bayesian Framew • Modelling Proteasome Dynamics in a Bayesian Framework • ODE Model • Proteaseome inhibitor • Thymoproteasome
ISBN-10	3-658-20166-5 / 3658201665
ISBN-13	978-3-658-20166-1 / 9783658201661
Zustand	Neuware